Study on preparation and quality of cefotiam hexetil hydrochloride tablet

JIA Wei; ZHANG Hongxia; FENG Zhiqiang; SU Lu

doi:10.3969/j.issn.1006-0111.2019.06.010

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Objective To study the preparation technology and quality of cefotiam hexetil hydrochloride tablet. Methods The disintegration time limit and dissolution of drug were taken as the main index.The original piece of reference was used to optimize the prescription process and preliminary study on its quality. Results The best prescription was determined by experiments:cefotiam hexetil hydrochloride tablets were prepared by dry granulation with anhydrous citric acid,alpha-cyclodextrin,microcrystalline cellulose,hydroxypropyl cellulose,silica,magnesium stearate and film-coated premix (gastric-soluble).The indexes of cefotiam hexetil hydrochloride tablet conformed to the Japanese Pharmaceutical Bureau Prescription (JPXV) standard. Conclusion The preparation technology of cefotiam hexetil hydrochloride tablet was feasible and the product had good stability.

Study on preparation and quality of cefotiam hexetil hydrochloride tablet

1. Xi'an Wanlong Pharmaceutical Co. Ltd, Xi'an 710075, China

2. Shaanxi Jiuzhou Pharmaceutical Co. Ltd, Xi'an 710000, China

Received Date: 2018-12-03

Rev Recd Date: 2019-07-07

Key words:

Abstract: Objective To study the preparation technology and quality of cefotiam hexetil hydrochloride tablet. Methods The disintegration time limit and dissolution of drug were taken as the main index.The original piece of reference was used to optimize the prescription process and preliminary study on its quality. Results The best prescription was determined by experiments:cefotiam hexetil hydrochloride tablets were prepared by dry granulation with anhydrous citric acid,alpha-cyclodextrin,microcrystalline cellulose,hydroxypropyl cellulose,silica,magnesium stearate and film-coated premix (gastric-soluble).The indexes of cefotiam hexetil hydrochloride tablet conformed to the Japanese Pharmaceutical Bureau Prescription (JPXV) standard. Conclusion The preparation technology of cefotiam hexetil hydrochloride tablet was feasible and the product had good stability.

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Reference (16)

[1]	徐铮奎.国际抗感染药物市场现状与前景分析[J].中国制药信息,2016(2):35-37.
[2]	DLAL K S,BRIDQEMAN M B.Anti-infective drugs[J].Nursing,2018,48(1):70.
[3]	TIAN Y,WANG Y N,HAN Y,et al.Isolation,identification and in silico toxicity predictions of two isomers from cefotiam hydrochloride[J].J Pharm Biomed Anal,2018,158(1):425-430.
[4]	QUEROL-FERRER V,ZINI R,TILLEMENT J P.The blood binding of cefotiam and cyclohexanol,metabolites of the prodrug cefotiam hexetil,in-vitro[J].J Pharm Pharmacol,1991,43(12):863-866.
[5]	MIZUTANI H,OHYANAGI S,SHIMIZU M.Anaphylaxis from cefotiam hexetil hydrochloride (CTM-HE) in an atopic nurse[J].Clin Exp Dermatol,1996,21(3):246.
[6]	KUCUKBOYACI N E,KEMMOTSU N,CHENG C E,et al.Functional connectivity of the hippocampus in temporal lobe epilepsy:feasibility of a task-regressed seed-based approach[J].Brain Connect,2013,3(5):464-474.
[7]	韩彬,刘立涛,邵振俊,等.进口头孢替安酯体内外抗菌作用的实验研究[J].四川生理科学杂志,2016,38(2):57-59.
[8]	杨晨,任凤英,杨红,等.顶空气相色谱法测定盐酸头孢替安酯原料药中残留溶剂含量[J].医药导报,2016,35(2):177-180.
[9]	任凤英,李强,杨晨,等.RP-HPLC法测定盐酸头孢替安酯的含量及有关物质[J].国外医药(抗生素分册),2012,33(6):253-257.
[10]	WANG D X,LING X,PENG H,et al.High-temperature analogy experimental investigation on dry granulating characteristic of rotating disk for waste heat utilization of molten slag[J].Appl Therm Eng,2017,125(10):846-855.
[11]	TAKEUCHI Y,YOSHIDA M,ITO A,et al.Uniformity of drug content during pharmaceutical dry granulating by roller compaction and tableting processes[J].J Drug Deliv Sci Technol,2009,19(2):119-124.
[12]	LAFONTAINE A,SANSELME M,CARTIGNY Y,et al.Characterization of the transition between the monohydrate and the anhydrous citric acid[J].J Therm Anal Calorim,2013,112(1):307-315.
[13]	杜昌群,杜昌勇.紫外分光光度法测定盐酸头孢替安酯片溶出度的方法[J].中国民康医学,2013,25(4):16-17.
[14]	国家药典委员会.中华人民共和国药典(四部)[S].北京:化学工业出版社,2015.
[15]	林集端,赵珺.PEG/α-环糊精准聚轮烷水凝胶与BSA相互作用的光谱学研究[J].化工进展,2016,35(11):3590-3594.
[16]	WANG J,WILLIAMSON G S,YANG H.Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release[J].Colloids Surf B Biointerfaces,2018,165(5):144-149.

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Study on preparation and quality of cefotiam hexetil hydrochloride tablet

doi: 10.3969/j.issn.1006-0111.2019.06.010

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