Pharmacokinetics study on matrine gels based on micro dialysis

GU Qing; ZHOUJianbin; XU Jianliang; ZHU Guohua; SHU Wei

doi:10.3969/j.issn.1006-0111.2019.06.006

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Objective To establish a pharmacokinetic method for simultaneous determination the drug concentration in the skin and blood for transdermal formulations,and to study the absorption and metabolism of matrine gel in vivo. Methods A micro dialysis probe-based skin-blood synchronous micro dialysis system was established.After the probe was implanted into the skin and jugular vein,the matrine gel was administered.The dialysate in the probe was continuously collected for 12 h.The concentration of the drug in the probe dialysate was determined by LC-MS. Results In this study,a two-site synchronous micro dialysis pharmacokinetic evaluation system was successfully established.After given matrine gel,the concentration,AUC and half-life of the drug in skin were significantly higher than that in blood. Conclusion The established micro dialysis system combined with LC-MS could provide a new technology platform for the pharmacokinetic study on transdermal formulations.

Pharmacokinetics study on matrine gels based on micro dialysis

Department of Pharmacy, Central Hospital of Shanghai Zhabei District, Shanghai 200070, China

Received Date: 2019-06-12

Rev Recd Date: 2019-10-24

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Abstract: Objective To establish a pharmacokinetic method for simultaneous determination the drug concentration in the skin and blood for transdermal formulations,and to study the absorption and metabolism of matrine gel in vivo. Methods A micro dialysis probe-based skin-blood synchronous micro dialysis system was established.After the probe was implanted into the skin and jugular vein,the matrine gel was administered.The dialysate in the probe was continuously collected for 12 h.The concentration of the drug in the probe dialysate was determined by LC-MS. Results In this study,a two-site synchronous micro dialysis pharmacokinetic evaluation system was successfully established.After given matrine gel,the concentration,AUC and half-life of the drug in skin were significantly higher than that in blood. Conclusion The established micro dialysis system combined with LC-MS could provide a new technology platform for the pharmacokinetic study on transdermal formulations.

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Pharmacokinetics study on matrine gels based on micro dialysis

doi: 10.3969/j.issn.1006-0111.2019.06.006

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