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Volume 36 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(4): 334-337

SHEN Liru, LI Ruihong, WANG Tailiang. Simultaneous determination of peimine and peiminine in Xiaoer Baotaikang granules by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 351-353. doi: 10.3969/j.issn.1006-0111.2016.04.017
Citation: YANG Lina, ZENG Qiping, CAO Yixiang, CAI Xiaohui, CHEN Jinshan. Simultaneous determination of seven active components in compound caulis polygoni multiflori mixture by HPLC of double wavelength[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 334-337. doi: 10.3969/j.issn.1006-0111.2018.04.010
shu

Simultaneous determination of seven active components in compound caulis polygoni multiflori mixture by HPLC of double wavelength

doi: 10.3969/j.issn.1006-0111.2018.04.010

  • The Pharmacy Department, the 175 th Hospital of PLA/the Affiliated Southeast Hospital of Xiamen University, Fujian Zhangzhou 363000, China

  • Received Date: 2017-11-24
  • Rev Recd Date: 2018-05-24
  • Objective To establish a double wavelength method for the simultaneous determination of ligustrazine hydrochloride, chlorogenic acid, ferulic acid, stibene glucoside, Lignin glycosides, asperosaponin Ⅵ and schizandrol A in compound caulis polygoni multiflori mixture. Methods The HPLC separation was performed on an Agilent ZORBAX SB-C18 column (250 mm×4.6 mm, 5 μm), gradient eluted with the mixture of acetonitrile and 0.1% phosphoric acid as mobile phase, the flow rate was 1 ml/min, the detection wavelength was 210 nm and 320 nm, and the column temperature was 25℃. Results There were good linear relationships in the determination of ligustrazine hydrochloride, chlorogenic acid, ferulic acid, stibene glucoside, Lignin glycosides, asperosaponin Ⅵ and schizandrol A (r ≥ 0.9997), with the average recovery rate of 102.33%, 100.29%, 100.18%, 99.95%, 99.23%, 101.61%, 99.28%, and the RSD were less than 3%. Conclusion The method was accurate, stable and reproducible and could be used for quality control of compound caulis polygoni multiflori mixture.
  • [1] 曾棋平, 杨丽娜, 曹毅祥, 等. 层次分析联合Box-Behnken效应面法优选复方首乌藤合剂提取工艺[J]. 中南药学, 2017, 15(1):48-52.
    [2] 杨丽娜, 曾棋平, 蔡小辉, 等. 复方首乌藤合剂高效液相指纹图谱研究[J]. 中南药学, 2018, 16(1):27-30.
    [3] 国家药典委员会. 中华人民共和国药典2015版(一部)[S]. 北京:中国医药科技出版社,2015
    [4] 江雪欣, 王佳茜. 波长变换HPLC法同时测定急支糖浆中6种活性成分[J]. 中国药师, 2017, 20(3):556-558.
    [5] 陈博年, 孙立伟, 张毅, 等. HPLC-MS/MS法同时测定心通口服液中10种活性成分[J]. 中草药, 2017, 48(12):2455-2460.
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    [7] 许丹丹. 五味子醇甲促觉醒及增强学习记忆功能作用[D]. 黑龙江中医药大学, 2017.
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    [10] 谢意, 郑礼胜, 雷勇胜. HPLC法同时测定拨云退翳丸中10种指标成分[J]. 中草药, 2016, 47(17):3039-3043.
    [11] 干国平, 朱红, 师磊, 等. 不同产地山合欢皮中(-)-丁香树脂酚-4-O-β-D-葡萄糖苷含量的比较[J]. 药物分析杂志, 2009, 29(4):606-608.
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Simultaneous determination of seven active components in compound caulis polygoni multiflori mixture by HPLC of double wavelength

doi: 10.3969/j.issn.1006-0111.2018.04.010
  • The Pharmacy Department, the 175 th Hospital of PLA/the Affiliated Southeast Hospital of Xiamen University, Fujian Zhangzhou 363000, China
  • Received Date: 2017-11-24
  • Rev Recd Date: 2018-05-24

Abstract: Objective To establish a double wavelength method for the simultaneous determination of ligustrazine hydrochloride, chlorogenic acid, ferulic acid, stibene glucoside, Lignin glycosides, asperosaponin Ⅵ and schizandrol A in compound caulis polygoni multiflori mixture. Methods The HPLC separation was performed on an Agilent ZORBAX SB-C18 column (250 mm×4.6 mm, 5 μm), gradient eluted with the mixture of acetonitrile and 0.1% phosphoric acid as mobile phase, the flow rate was 1 ml/min, the detection wavelength was 210 nm and 320 nm, and the column temperature was 25℃. Results There were good linear relationships in the determination of ligustrazine hydrochloride, chlorogenic acid, ferulic acid, stibene glucoside, Lignin glycosides, asperosaponin Ⅵ and schizandrol A (r ≥ 0.9997), with the average recovery rate of 102.33%, 100.29%, 100.18%, 99.95%, 99.23%, 101.61%, 99.28%, and the RSD were less than 3%. Conclusion The method was accurate, stable and reproducible and could be used for quality control of compound caulis polygoni multiflori mixture.

SHEN Liru, LI Ruihong, WANG Tailiang. Simultaneous determination of peimine and peiminine in Xiaoer Baotaikang granules by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 351-353. doi: 10.3969/j.issn.1006-0111.2016.04.017
Citation: YANG Lina, ZENG Qiping, CAO Yixiang, CAI Xiaohui, CHEN Jinshan. Simultaneous determination of seven active components in compound caulis polygoni multiflori mixture by HPLC of double wavelength[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 334-337. doi: 10.3969/j.issn.1006-0111.2018.04.010
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