Preparation materials, drug loading and modification of nanoparticles as anticancer drug carrier

HAN Ling; SUN Zhiguo; LU Ying

doi:10.3969/j.issn.1006-0111.2018.04.005

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2018 > 36(4): 307-312,350

HAN Ling, SUN Zhiguo, LU Ying. Preparation materials, drug loading and modification of nanoparticles as anticancer drug carrier[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 307-312,350. doi: 10.3969/j.issn.1006-0111.2018.04.005

Citation:

HAN Ling, SUN Zhiguo, LU Ying. Preparation materials, drug loading and modification of nanoparticles as anticancer drug carrier[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 307-312,350. doi: 10.3969/j.issn.1006-0111.2018.04.005

Preparation materials, drug loading and modification of nanoparticles as anticancer drug carrier

doi: 10.3969/j.issn.1006-0111.2018.04.005

Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2017-10-14
Rev Recd Date: 2018-01-10

Abstract

As the carrier of antitumor drugs, nanoparticles have many advantages, such as improving drug targeting, enhancing stability and reducing drug toxicity. In recent years, studies on anticancer drug nanoparticles have made great progress. This paper reviews the materials, drug loading and modification methods of anticancer drug nanoparticles.
- nanoparticle,
- antitumor,
- drug delivery system

References

[1]	SHI J, KANTOFF PW, WOOSTER R, et al. Cancer nanomedicine:progress, challenges and opportunities[J]. Nat Rev Cancer, 2017, 17(1):20-37.
[2]	陈清江, 张明智, 陈小兵. 抗肿瘤纳米药物载体材料的安全性[J]. 中国组织工程研究与临床康复, 2010, 14(47):8861-8864.
[3]	PRADOS J,CABEZA L,ORTIZ R, et al. Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles[J]. IJN, 2015, 10:1291-1306.
[4]	MA W, CHEN M, KAUSHAL S, et al. PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses[J]. Int J Nanomed, 2012, 7:1475-1487.
[5]	LIU R, LI D, HE B, et al. Anti-tumor drug delivery of pH-sensitive poly(ethylene glycol)-poly (L -histidine-)-poly (L -lactide) nanoparticles[J]. J Controll Releas, 2011, 152(1):49-56.
[6]	LEE SJ, YHEE JY, KIM SH, et al. Biocompatible gelatin nanoparticles for tumor-targeted delivery of polymerized siRNA in tumor-bearing mice[J]. J Controll Release, 2013, 172(1):358-366.
[7]	GAO C, TANG F, ZHANG J, et al. Glutathione-responsive nanoparticles based on a sodium alginate derivative for selective release of doxorubicin in tumor cells[J]. J Mater Chem B, 2017, 5(12):2337-2346.
[8]	ABOUTALEB E, ATYABI F, KHOSHAYAND MR, et al. Improved brain delivery of vincristine using dextran sulfate complex solid lipid nanoparticles:optimization and in vivo evaluation[J]. J Biomed Mater Res A, 2014, 102(7):2125-2136.
[9]	CHEN Y, CHEN H, SHI J. Inorganic nanoparticle-based drug codelivery nanosystems to overcome the multidrug resistance of cancer cells[J]. Mol Pharm, 2014, 11(8):2495-2510.
[10]	HE X, HAI L, SU J, et al. One-pot synthesis of sustained-released doxorubicin silica nanoparticles for aptamer targeted delivery to tumor cells[J]. Nanoscale, 2011, 3(7):2936-2942.
[11]	REJINOLD NS, THOMAS RG, MUTHIAH M, et al. Breast tumor targetable Fe₃O₄ embedded thermo-responsive nanoparticles for radiofrequency assisted drug delivery[J]. J Biomed Nanotechnol, 2016, 12(1):43-55.
[12]	ZHAO X, YANG L, LI X, et al. Functionalized graphene oxide nanoparticles for cancer cell-specific delivery of antitumor drug[J]. Bioconjug Chem, 2015, 26(1):128-136.
[13]	PARVEEN S, SAHOO SK. Long circulating chitosan/PEG blended PLGA nanoparticle for tumor drug delivery[J]. Eur J Pharmacol, 2011, 670(2-3):372-383.
[14]	MOCAN L, MATEA C, TABARAN FA, et al. Selective exvivo photothermal nano-therapy of solid liver tumors mediated by albumin conjugated gold nanoparticles[J]. Biomaterials, 2017, 119:33-42.
[15]	MICHA JP, GOLDSTEIN BH, BIRK CL, et al. Abraxane in the treatment of ovarian cancer:the absence of hypersensitivity reactions[J]. Gynecol Oncol, 2006, 100(2):437-438.
[16]	KUMAR M, GUPTA D, SINGH G, et al. Novel polymeric nanoparticles for intracellular delivery of peptide Cargos:antitumor efficacy of the BCL-2 conversion peptide NuBCP-9[J]. Cancer Res, 2014, 74(12):3271-3281.
[17]	Phase I intratumoral Pbi-shRNA STMN1 LP in advanced and/or metastatic cancer (STMN1-LP)[DB/OL]. Clinical Trials.gov:US National Library of Medicine,[2012-01-06].[2017-09-20]. https://clinicaltrials.gov/ct2/show/NCT01505153term.
[18]	LV S, TANG Z, LI M, et al. Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer[J]. Biomaterials, 2014, 35(23):6118-6129.
[19]	LIU Q, LI RT, QIAN HQ, et al. Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles[J]. Biomaterials, 2013, 34(29):7191-7203.
[20]	KOUCHAKZADEH H,SHOJAOSADATI SA,TAHMA-SEBI F, et al. Optimization of an anti-HER2 monoclonal antibody targeted delivery system using PEGylated human serum albumin nanoparticles[J]. Int J Pharm, 2013, 447(12):62-69.
[21]	GAN CW, FENG SS. Transferrin-conjugated nanoparticles of poly(lactide)-D-alpha-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier[J]. Biomaterials, 2010, 31(30):7748-7757.
[22]	KIM YH, JEON J, HONG SH, et al. Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125[J]. Small, 2011, 7(14):2052-2060.
[23]	JOKERST JV, MIAO Z, ZAVALETA C, et al. Affibody-functionalized gold silica nanoparticles for raman molecular imaging of the epidermal growth factor receptor[J]. Small, 2011, 7(5):625-633.
[24]	HWANG DW, SON S, Jang J, et al. A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA[J]. Biomaterials, 2011, 32(21):4968-4975.
[25]	CERCHIA L, DE FRANCISCIS V. Targeting cancer cells with nucleic acid aptamers[J]. Trends Biotechnol, 2010, 28(10):517-525.
[26]	YANG SJ, LIN FH, TSAI KC, et al. Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells[J]. Bioconjug Chem, 2010, 21(4):679-689.
[27]	TAHERI A, DINARVAND R, ATYABI F, et al. Targeted delivery of methotrexate to tumor cells using biotin functionalized methotrexate-human serum albumin conjugated nanoparticles[J]. J Biomed Nanotechnol, 2011, 7(6):743-753.
[28]	CAI X, LI X, LIU Y, et al. Galactose decorated acid-labile nanoparticles encapsulating quantum dots for enhanced cellular uptake and subcellular localization[J]. Pharm Res, 2012, 29(8):2167-2179.
[29]	YAO XK, ZHU Q, LI CH, et al. Carbamoylmannose enhances tumor targeting of supramolecular nanoparticles formed through host-guest complexation of a pair of homopolymers[J]. J Materi Chem B, 2016, 5(4):834-848.
[30]	SUN H, BENJAMINSEN RV, ALMADAL K, et al. Hyaluronic acid immobilized polyacrylamide nanoparticle sensors for CD44 receptor targeting and pH measurement in cells[J]. Bioconjug Chem, 2012, 23(11):2247-2255.
[31]	AYDOGAN B, LI J, RAJH T, et al. AuNP-DG:deoxyglucose-labeled gold nanoparticles as X-ray computed tomography contrast agents for cancer imaging[J]. Mol Imag Biol, 2010, 12(5):463-467.
[32]	YUK SH, OH KS, SUN HC, et al. Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging[J]. Biomacromolecules, 2011, 12(6):2335-2343.
[33]	ZU Y, LI M, ZHAO X, et al. Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery[J]. Int J Nanomed, 2013, 8:1207-1222.
[34]	SUN W, XIE C, WANG H, et al. Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain[J]. Biomaterials, 2004, 25(15):3065-3071.
[35]	BAZILE D, PRUD'me C, BASSOULLET MT, et al. Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system[J]. J Pharm Sci, 1995, 84(4):493-498.
[36]	XI J, QIN J, FAN L. Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery[J]. Int J Nanomed, 2012, 7:5235-5247.
[37]	TANAKA K, KANAZAWA T, SHIBATA Y, et al. Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery[J]. Int J Pharm, 2010, 396(1-2):229-238.
[38]	WANG YC, WANG F, SUN TM, et al. Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells[J]. Bioconjug Chem, 2011, 22(10):1939-1945.
[39]	WU M, ZHANG D, ZENG Y, et al. Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy[J]. Nanotechnology, 2015, 26(11):115102.
[40]	WANG C, HO PC, LIM LY. Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells[J]. Int J Pharm, 2010, 400(12):201-210.
[41]	CHEN H, LIU R, NAN W, et al. Abstract 5659:Surface modification of epirubicin-loaded PLGA nanoparticle with biotinylated chitosan enhances anti-cancer efficacy in breast cancer cells[J]. Cancer Res, 2013, 73(8):5659-5659.
[42]	RAO L, XU JH, CAI B, et al. Synthetic nanoparticles camouflaged with biomimetic erythrocyte membranes for reduced reticuloendothelial system uptake[J]. Nanotechnology, 2016, 27(8):085106.
[43]	PARODI A, QUATTROCCHI N, VAN DE VEN AL, et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions[J]. Nat Nanotechnol, 2013, 8(1):61-68.
[44]	GAO C, LIN Z, JURADO-S NCHEZ B, et al. Stem cell membrane-coated nanogels for highly efficient in vivo tumor targeted drug delivery[J]. Small, 2016, 12(30):4056-4062.
[45]	FANG RH, HU CM, LUK BT, et al. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery[J]. Nano Lett, 2014, 14(4):2181-2188.
[46]	LO GIUDICE MC, MEDER F, POLO E, et al. Constructing bifunctional nanoparticles for dual targeting:improved grafting and surface recognition assessment of multiple ligand nanoparticles[J]. Nanoscale, 2016, 8(38):16969-16975.
[47]	DOOLITTLE E, PEIRIS PM, DORON G, et al. Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis[J]. ACS Nano, 2015, 9(8):8012-8021.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Preparation materials, drug loading and modification of nanoparticles as anticancer drug carrier

Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2017-10-14

Rev Recd Date: 2018-01-10

Key words:

Abstract: As the carrier of antitumor drugs, nanoparticles have many advantages, such as improving drug targeting, enhancing stability and reducing drug toxicity. In recent years, studies on anticancer drug nanoparticles have made great progress. This paper reviews the materials, drug loading and modification methods of anticancer drug nanoparticles.

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Reference (47)

[1]	SHI J, KANTOFF PW, WOOSTER R, et al. Cancer nanomedicine:progress, challenges and opportunities[J]. Nat Rev Cancer, 2017, 17(1):20-37.
[2]	陈清江, 张明智, 陈小兵. 抗肿瘤纳米药物载体材料的安全性[J]. 中国组织工程研究与临床康复, 2010, 14(47):8861-8864.
[3]	PRADOS J,CABEZA L,ORTIZ R, et al. Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles[J]. IJN, 2015, 10:1291-1306.
[4]	MA W, CHEN M, KAUSHAL S, et al. PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses[J]. Int J Nanomed, 2012, 7:1475-1487.
[5]	LIU R, LI D, HE B, et al. Anti-tumor drug delivery of pH-sensitive poly(ethylene glycol)-poly (L -histidine-)-poly (L -lactide) nanoparticles[J]. J Controll Releas, 2011, 152(1):49-56.
[6]	LEE SJ, YHEE JY, KIM SH, et al. Biocompatible gelatin nanoparticles for tumor-targeted delivery of polymerized siRNA in tumor-bearing mice[J]. J Controll Release, 2013, 172(1):358-366.
[7]	GAO C, TANG F, ZHANG J, et al. Glutathione-responsive nanoparticles based on a sodium alginate derivative for selective release of doxorubicin in tumor cells[J]. J Mater Chem B, 2017, 5(12):2337-2346.
[8]	ABOUTALEB E, ATYABI F, KHOSHAYAND MR, et al. Improved brain delivery of vincristine using dextran sulfate complex solid lipid nanoparticles:optimization and in vivo evaluation[J]. J Biomed Mater Res A, 2014, 102(7):2125-2136.
[9]	CHEN Y, CHEN H, SHI J. Inorganic nanoparticle-based drug codelivery nanosystems to overcome the multidrug resistance of cancer cells[J]. Mol Pharm, 2014, 11(8):2495-2510.
[10]	HE X, HAI L, SU J, et al. One-pot synthesis of sustained-released doxorubicin silica nanoparticles for aptamer targeted delivery to tumor cells[J]. Nanoscale, 2011, 3(7):2936-2942.
[11]	REJINOLD NS, THOMAS RG, MUTHIAH M, et al. Breast tumor targetable Fe₃O₄ embedded thermo-responsive nanoparticles for radiofrequency assisted drug delivery[J]. J Biomed Nanotechnol, 2016, 12(1):43-55.
[12]	ZHAO X, YANG L, LI X, et al. Functionalized graphene oxide nanoparticles for cancer cell-specific delivery of antitumor drug[J]. Bioconjug Chem, 2015, 26(1):128-136.
[13]	PARVEEN S, SAHOO SK. Long circulating chitosan/PEG blended PLGA nanoparticle for tumor drug delivery[J]. Eur J Pharmacol, 2011, 670(2-3):372-383.
[14]	MOCAN L, MATEA C, TABARAN FA, et al. Selective exvivo photothermal nano-therapy of solid liver tumors mediated by albumin conjugated gold nanoparticles[J]. Biomaterials, 2017, 119:33-42.
[15]	MICHA JP, GOLDSTEIN BH, BIRK CL, et al. Abraxane in the treatment of ovarian cancer:the absence of hypersensitivity reactions[J]. Gynecol Oncol, 2006, 100(2):437-438.
[16]	KUMAR M, GUPTA D, SINGH G, et al. Novel polymeric nanoparticles for intracellular delivery of peptide Cargos:antitumor efficacy of the BCL-2 conversion peptide NuBCP-9[J]. Cancer Res, 2014, 74(12):3271-3281.
[17]	Phase I intratumoral Pbi-shRNA STMN1 LP in advanced and/or metastatic cancer (STMN1-LP)[DB/OL]. Clinical Trials.gov:US National Library of Medicine,[2012-01-06].[2017-09-20]. https://clinicaltrials.gov/ct2/show/NCT01505153term.
[18]	LV S, TANG Z, LI M, et al. Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer[J]. Biomaterials, 2014, 35(23):6118-6129.
[19]	LIU Q, LI RT, QIAN HQ, et al. Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles[J]. Biomaterials, 2013, 34(29):7191-7203.
[20]	KOUCHAKZADEH H,SHOJAOSADATI SA,TAHMA-SEBI F, et al. Optimization of an anti-HER2 monoclonal antibody targeted delivery system using PEGylated human serum albumin nanoparticles[J]. Int J Pharm, 2013, 447(12):62-69.
[21]	GAN CW, FENG SS. Transferrin-conjugated nanoparticles of poly(lactide)-D-alpha-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier[J]. Biomaterials, 2010, 31(30):7748-7757.
[22]	KIM YH, JEON J, HONG SH, et al. Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125[J]. Small, 2011, 7(14):2052-2060.
[23]	JOKERST JV, MIAO Z, ZAVALETA C, et al. Affibody-functionalized gold silica nanoparticles for raman molecular imaging of the epidermal growth factor receptor[J]. Small, 2011, 7(5):625-633.
[24]	HWANG DW, SON S, Jang J, et al. A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA[J]. Biomaterials, 2011, 32(21):4968-4975.
[25]	CERCHIA L, DE FRANCISCIS V. Targeting cancer cells with nucleic acid aptamers[J]. Trends Biotechnol, 2010, 28(10):517-525.
[26]	YANG SJ, LIN FH, TSAI KC, et al. Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells[J]. Bioconjug Chem, 2010, 21(4):679-689.
[27]	TAHERI A, DINARVAND R, ATYABI F, et al. Targeted delivery of methotrexate to tumor cells using biotin functionalized methotrexate-human serum albumin conjugated nanoparticles[J]. J Biomed Nanotechnol, 2011, 7(6):743-753.
[28]	CAI X, LI X, LIU Y, et al. Galactose decorated acid-labile nanoparticles encapsulating quantum dots for enhanced cellular uptake and subcellular localization[J]. Pharm Res, 2012, 29(8):2167-2179.
[29]	YAO XK, ZHU Q, LI CH, et al. Carbamoylmannose enhances tumor targeting of supramolecular nanoparticles formed through host-guest complexation of a pair of homopolymers[J]. J Materi Chem B, 2016, 5(4):834-848.
[30]	SUN H, BENJAMINSEN RV, ALMADAL K, et al. Hyaluronic acid immobilized polyacrylamide nanoparticle sensors for CD44 receptor targeting and pH measurement in cells[J]. Bioconjug Chem, 2012, 23(11):2247-2255.
[31]	AYDOGAN B, LI J, RAJH T, et al. AuNP-DG:deoxyglucose-labeled gold nanoparticles as X-ray computed tomography contrast agents for cancer imaging[J]. Mol Imag Biol, 2010, 12(5):463-467.
[32]	YUK SH, OH KS, SUN HC, et al. Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging[J]. Biomacromolecules, 2011, 12(6):2335-2343.
[33]	ZU Y, LI M, ZHAO X, et al. Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery[J]. Int J Nanomed, 2013, 8:1207-1222.
[34]	SUN W, XIE C, WANG H, et al. Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain[J]. Biomaterials, 2004, 25(15):3065-3071.
[35]	BAZILE D, PRUD'me C, BASSOULLET MT, et al. Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system[J]. J Pharm Sci, 1995, 84(4):493-498.
[36]	XI J, QIN J, FAN L. Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery[J]. Int J Nanomed, 2012, 7:5235-5247.
[37]	TANAKA K, KANAZAWA T, SHIBATA Y, et al. Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery[J]. Int J Pharm, 2010, 396(1-2):229-238.
[38]	WANG YC, WANG F, SUN TM, et al. Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells[J]. Bioconjug Chem, 2011, 22(10):1939-1945.
[39]	WU M, ZHANG D, ZENG Y, et al. Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy[J]. Nanotechnology, 2015, 26(11):115102.
[40]	WANG C, HO PC, LIM LY. Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells[J]. Int J Pharm, 2010, 400(12):201-210.
[41]	CHEN H, LIU R, NAN W, et al. Abstract 5659:Surface modification of epirubicin-loaded PLGA nanoparticle with biotinylated chitosan enhances anti-cancer efficacy in breast cancer cells[J]. Cancer Res, 2013, 73(8):5659-5659.
[42]	RAO L, XU JH, CAI B, et al. Synthetic nanoparticles camouflaged with biomimetic erythrocyte membranes for reduced reticuloendothelial system uptake[J]. Nanotechnology, 2016, 27(8):085106.
[43]	PARODI A, QUATTROCCHI N, VAN DE VEN AL, et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions[J]. Nat Nanotechnol, 2013, 8(1):61-68.
[44]	GAO C, LIN Z, JURADO-S NCHEZ B, et al. Stem cell membrane-coated nanogels for highly efficient in vivo tumor targeted drug delivery[J]. Small, 2016, 12(30):4056-4062.
[45]	FANG RH, HU CM, LUK BT, et al. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery[J]. Nano Lett, 2014, 14(4):2181-2188.
[46]	LO GIUDICE MC, MEDER F, POLO E, et al. Constructing bifunctional nanoparticles for dual targeting:improved grafting and surface recognition assessment of multiple ligand nanoparticles[J]. Nanoscale, 2016, 8(38):16969-16975.
[47]	DOOLITTLE E, PEIRIS PM, DORON G, et al. Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis[J]. ACS Nano, 2015, 9(8):8012-8021.

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Preparation materials, drug loading and modification of nanoparticles as anticancer drug carrier

doi: 10.3969/j.issn.1006-0111.2018.04.005

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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