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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(1): 30-33,54

SHEN Liru, LI Ruihong, WANG Tailiang. Simultaneous determination of peimine and peiminine in Xiaoer Baotaikang granules by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 351-353. doi: 10.3969/j.issn.1006-0111.2016.04.017
Citation: HOU Cheng, LU Guangzhao, ZHANG He, LU Ying, ZHONG Yanqiang, ZOU Hao. Evaluation of the effect of different routes of administrating flumazenil against hypnosis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 30-33,54. doi: 10.3969/j.issn.1006-0111.2018.01.006
shu

Evaluation of the effect of different routes of administrating flumazenil against hypnosis

doi: 10.3969/j.issn.1006-0111.2018.01.006

  • Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2017-09-28
  • Rev Recd Date: 2017-10-23
  • Objective To study the effect of flumazenil on hypnotic mice induced by diazepam and zolpidem, and to evaluate the possibility of flumazenil oral administration. Methods First, Kunming mice were injected intraperitoneally with normal saline and sodium pentobarbital (S + W), diazepam and pentobarbital sodium (D + W), zolpidem and pentobarbital sodium (Z + W). The hypnotic effect of diazepam and zolpidem on prolonging the sleep time of pentobarbital sodium would be verified by (D + W) group and (Z + W) group. Then the mice were injected intraperitoneally with flumazenil. The sleep time was used as the evaluation index to evaluate the effect of flumazenil against hypnosis. Finally, the oral administration of flumazenil was observed against hypnosis, which was evaluated by using sleep time as an index. Results Compared with the control group (S+W), the diazepam group (D+W) and the zolpidem group (Z+W) significantly prolonged the sleep time induced by pentobarbital sodium (P<0.001,P<0.05);After Intraperitoneal injection of flumazenil,compared with the diazepam group (D+W) and the zolpidem group (Z+W),the sleep time of the diazepam group[F(ip)+D+W] and the zolpidem group[F(ip)+Z+W] were significantly shorter (P<0.001, P<0.05);After oral administration of flumazenil, the sleep time of the diazepam group[F(ig)+D+W] and the zolpidem group[F(ig)+Z+W] were also significantly shorter (P<0.001,P<0.05). Conclusion Flumazenil, whether intraperitoneal injection or intragastric administration, could antagonize the hypnotic effect of diazepam and zolpidem. It was proved that oral administration of flumazenil had the same effect compared with intraperitoneal injection of flumazenil, which provided the possibility of preparation of oral administration of flumazenil.
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    [7] 中华人民共和国卫生部. 新药(西药)临床前研究指导原则汇编[M]. 中华人民共和国卫生部药政局, 1993.
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Evaluation of the effect of different routes of administrating flumazenil against hypnosis

doi: 10.3969/j.issn.1006-0111.2018.01.006
  • Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2017-09-28
  • Rev Recd Date: 2017-10-23

Abstract: Objective To study the effect of flumazenil on hypnotic mice induced by diazepam and zolpidem, and to evaluate the possibility of flumazenil oral administration. Methods First, Kunming mice were injected intraperitoneally with normal saline and sodium pentobarbital (S + W), diazepam and pentobarbital sodium (D + W), zolpidem and pentobarbital sodium (Z + W). The hypnotic effect of diazepam and zolpidem on prolonging the sleep time of pentobarbital sodium would be verified by (D + W) group and (Z + W) group. Then the mice were injected intraperitoneally with flumazenil. The sleep time was used as the evaluation index to evaluate the effect of flumazenil against hypnosis. Finally, the oral administration of flumazenil was observed against hypnosis, which was evaluated by using sleep time as an index. Results Compared with the control group (S+W), the diazepam group (D+W) and the zolpidem group (Z+W) significantly prolonged the sleep time induced by pentobarbital sodium (P<0.001,P<0.05);After Intraperitoneal injection of flumazenil,compared with the diazepam group (D+W) and the zolpidem group (Z+W),the sleep time of the diazepam group[F(ip)+D+W] and the zolpidem group[F(ip)+Z+W] were significantly shorter (P<0.001, P<0.05);After oral administration of flumazenil, the sleep time of the diazepam group[F(ig)+D+W] and the zolpidem group[F(ig)+Z+W] were also significantly shorter (P<0.001,P<0.05). Conclusion Flumazenil, whether intraperitoneal injection or intragastric administration, could antagonize the hypnotic effect of diazepam and zolpidem. It was proved that oral administration of flumazenil had the same effect compared with intraperitoneal injection of flumazenil, which provided the possibility of preparation of oral administration of flumazenil.

SHEN Liru, LI Ruihong, WANG Tailiang. Simultaneous determination of peimine and peiminine in Xiaoer Baotaikang granules by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 351-353. doi: 10.3969/j.issn.1006-0111.2016.04.017
Citation: HOU Cheng, LU Guangzhao, ZHANG He, LU Ying, ZHONG Yanqiang, ZOU Hao. Evaluation of the effect of different routes of administrating flumazenil against hypnosis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 30-33,54. doi: 10.3969/j.issn.1006-0111.2018.01.006
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