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Volume 36 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(1): 13-17

LIU Dan, ZHANG Jundong, LIAN Yunfei, FANG Qiuyu, LI Juan. Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 13-17. doi: 10.3969/j.issn.1006-0111.2018.01.003
Citation: LIU Dan, ZHANG Jundong, LIAN Yunfei, FANG Qiuyu, LI Juan. Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 13-17. doi: 10.3969/j.issn.1006-0111.2018.01.003
shu

Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles

doi: 10.3969/j.issn.1006-0111.2018.01.003
  • 1.

    School of pharmacy, China Pharmaceutical University, Nanjng 211198, China

  • 2.

    Haohai Biotechnology Co. Ltd, Shanghai 201600, China

  • Received Date: 2017-02-15
  • Rev Recd Date: 2017-12-28
  • Core-shell-type lipid-polymer hybrid nanoparticles(CSLPHNs) are composed by a biodegradable polymeric core coated with single or multiple layers of biomimetic lipids, which combine the benefits of polymeric nanoparticles and liposomes. CSLPHNs have the advantages of small particle size, high drug loading, good biocompatibility and controlled release capability. It has wide applications as a novel drug delivery system. This review gives a brief introduction in characteristics, preparation methods and applications of CSLPHNs, specifically summarizes the developments in the fields of ophthalmic drug delivery, tumor therapy and medical diagnostic imaging.
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    [2] Hadinoto K, Sundaresan A, Cheow WS. Lipid polymer hybrid nanoparticles as a new generation therapeutic delivery platform:a review[J].Eur J Pharm Biopharm, 2013, 85(3Pt A):427-443.
    [3] 赵一擎, 刘颖, 冯年平. 脂质聚合物纳米粒的研究进展[J]. 华西药学杂志, 2014, 29(5):602-605.
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    [13] Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010:a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012, 380(9859):2224-2260.
    [14] Krishnamurthy S, Vaiyapuri R, Zhang L, et al. Lipid-coated polymeric nanoparticles for cancer drug delivery[J].Biomater Sci, 2015, 3(7):923-936.
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    [21] Li L, Xiang D, Shigdar S, et al. Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells[J]. Int J Nanomedicine, 2014, 9:1083-1096.
    [22] Zhang LJ, Wu B, Zhou W, et al. Two-component reduction-sensitive lipid polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy[J]. Biomater Sci, 2016, 5(1):98-110.
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Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles

doi: 10.3969/j.issn.1006-0111.2018.01.003
  • 1. School of pharmacy, China Pharmaceutical University, Nanjng 211198, China
  • 2. Haohai Biotechnology Co. Ltd, Shanghai 201600, China
  • Received Date: 2017-02-15
  • Rev Recd Date: 2017-12-28

Abstract: Core-shell-type lipid-polymer hybrid nanoparticles(CSLPHNs) are composed by a biodegradable polymeric core coated with single or multiple layers of biomimetic lipids, which combine the benefits of polymeric nanoparticles and liposomes. CSLPHNs have the advantages of small particle size, high drug loading, good biocompatibility and controlled release capability. It has wide applications as a novel drug delivery system. This review gives a brief introduction in characteristics, preparation methods and applications of CSLPHNs, specifically summarizes the developments in the fields of ophthalmic drug delivery, tumor therapy and medical diagnostic imaging.

LIU Dan, ZHANG Jundong, LIAN Yunfei, FANG Qiuyu, LI Juan. Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 13-17. doi: 10.3969/j.issn.1006-0111.2018.01.003
Citation: LIU Dan, ZHANG Jundong, LIAN Yunfei, FANG Qiuyu, LI Juan. Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 13-17. doi: 10.3969/j.issn.1006-0111.2018.01.003
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