DONG Wei, YAN Jianwei, TAN Qiaoling, YE Sen. Effect of the curcumin on expression of IL-2 and IL-6 of hippocampus in pentylenetetrazol-induced epilepsy in rats[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 354-356. doi: 10.3969/j.issn.1006-0111.2016.04.018
| Citation:
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DONG Wei, YAN Jianwei, TAN Qiaoling, YE Sen. Effect of the curcumin on expression of IL-2 and IL-6 of hippocampus in pentylenetetrazol-induced epilepsy in rats[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 354-356. doi: 10.3969/j.issn.1006-0111.2016.04.018
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Effect of the curcumin on expression of IL-2 and IL-6 of hippocampus in pentylenetetrazol-induced epilepsy in rats
- Received Date: 2015-08-27
- Rev Recd Date:
2016-03-04
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Abstract
Objective To investigate the mechanism of anti-epileptic effect of the curcumin. Methods The SD rats were injected intraperitoneally with pentylenetetrazol kindling 25.0 mg/kg to induce a rat epilepsy model. All of the treatments were performed once a day continuously for 28 days. The rats in blank group and model group received 5 ml of normal saline. The rats in the high and low curcumin group were given 200 mg/kg and 100 mg/kg of curcumin once a day, respectively. The rats in the sodium valproate (VPA) group were given 400 mg/kg of VPA once a day by gavage. After treatment, the seizures level was recorded by using the Racine's six point grading scale, and the expression of IL-2 and IL-6 of hippocampus were detected by the enzyme linked immunoassay (ELISA). Results The seizures level was reduced by curcumin in epileptic rats. The expressions of IL-2 and IL-6 of the model group were significantly higher than those of the blank group (P<0.05), while those rats of the anti-epileptic groups, including high dose group and low dose group, were lower than those rats of the model group (P<0.05). When compared with the curcumin low dose group, the expression of IL-2 and IL-6 of curcumin high dose group is lower (P<0.05). There was no significant difference between the high dose curcumin group and VPA group (P>0.05). Conclusion The curcumin can reduce the seizure level in rats, it shows some anti-epileptic effets and dose-dependently, which may be through down-regulating the expression of IL-2 and IL-6 in hippocampus.
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