LI Zhiyuan, ZHANG Xiaodong, WANG Xinhong, ZHOU Duo. Experimental study on physical dependence of total Ervatamia yunnansis alkaloid[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 327-329. doi: 10.3969/j.issn.1006-0111.2016.04.011
| Citation:
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LI Zhiyuan, ZHANG Xiaodong, WANG Xinhong, ZHOU Duo. Experimental study on physical dependence of total Ervatamia yunnansis alkaloid[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 327-329. doi: 10.3969/j.issn.1006-0111.2016.04.011
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Experimental study on physical dependence of total Ervatamia yunnansis alkaloid
- 1.
No. 22 Hospital of PLA, Golmud 816099, China;Center for New Drug Evaluation, Second Military Medical University, Shanghai 200433, China
- 2.
Center for New Drug Evaluation, Second Military Medical University, Shanghai 200433, China
- 3.
No. 22 Hospital of PLA, Golmud 816099, China
- Received Date: 2016-02-19
- Rev Recd Date:
2016-05-24
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Abstract
Objective To evaluate the physical dependence of total Ervatamia yunnansis alkaloid. Methods The physical dependence of total Ervatamia yunnansis alkaloid was observed by jump test in mice and spontaneous withdrawal test in rats. Results In the jump test, after injecting total Ervatamia yunnansis alkaloid (total dosage of 140 and 430 mg/kg) for 7 days continuously, the mice didn't show any withdrawal symptom and the loss of body weight. In the spontaneous withdrawal test, two dosages of total Ervatamia yunnansis alkaloid (total dosage of 210 and 775 mg/kg) were continuously given for 30 days. The withdrawal response and the loss of body weight were not found in rats after drug withdrawal. Conclusion Total Ervatamia yunnansis alkaloid showed no obvious withdrawal symptoms in mice and rats, which suggests that it has no physical dependence.
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