GUO Min, ZHOU Bo, QIAO Hongqun, BAI Wenxia, LIU Jing. Study on skin irritation and allergenicity by indomethacin emulsion[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 324-326,347. doi: 10.3969/j.issn.1006-0111.2016.04.010
| Citation:
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GUO Min, ZHOU Bo, QIAO Hongqun, BAI Wenxia, LIU Jing. Study on skin irritation and allergenicity by indomethacin emulsion[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 324-326,347. doi: 10.3969/j.issn.1006-0111.2016.04.010
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Study on skin irritation and allergenicity by indomethacin emulsion
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Jiangsu Provincial Institute of Material Medica, Jiangsu Center for Safety Evaluation of Drugs, Nanjing 210009, China
- Received Date: 2015-01-21
- Rev Recd Date:
2016-03-04
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Abstract
Objective Study on skin irritation and allergenicity of indomethacin emulsion, in order to provide theoretical basis for clinical safe medication. Methods New Zealand white rabbits were used to test skin irritation, given 0.5g test substance for 14 days. The skin irritation was observed in the two groups with eight rabbits each during the experiment. Six rabbits in each group were sacrificed 72 hours after the last medication and skin tissues were taken for histopathology examination; and the skin tissues of remaining two rabbits were taken for histopathology examination in 14th day after the last medication. Guinea pigs were used to test skin allergenicity, given 0.5g test substance on day 0, 7, 14 for local induction. On day 28, the animal subjects were given 0.4g test substance on non-administration skin of guinea pigs for local excitation. Results Slight irritation of indomethacin emulsion on normal or damaged skin was observed but it is reversible after withdrawal for rabbits. Sensitization effect on the skin of guinea pig was not found. Conclusion Indomethacin emulsion is not suitable to long-term use clinically, and skin irritation need to pay more attention.
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