Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 34 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(4): 289-291,296

HU Dongmei, CHEN Xiaoling, LU Yang, FANG Minfeng, WANG Jingwen, WEN Aidong. Research progress on hepatoprotective effects of Erzhiwan and its components[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 289-291,296. doi: 10.3969/j.issn.1006-0111.2016.04.001
Citation: HU Dongmei, CHEN Xiaoling, LU Yang, FANG Minfeng, WANG Jingwen, WEN Aidong. Research progress on hepatoprotective effects of Erzhiwan and its components[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 289-291,296. doi: 10.3969/j.issn.1006-0111.2016.04.001
shu

Research progress on hepatoprotective effects of Erzhiwan and its components

doi: 10.3969/j.issn.1006-0111.2016.04.001
  • 1.

    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;College of Life Science, Northwest University, Xi'an 710069, China

  • 2.

    No. 63 Troops, The Air Force of 94647, Fuzhou 350026, China

  • 3.

    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China

  • 4.

    College of Life Science, Northwest University, Xi'an 710069, China

  • Received Date: 2015-08-28
  • Rev Recd Date: 2015-10-19
  • Erzhiwan includes two components of Chinese herbal medicines-Ligustri Lucidi Fructus and Herba Ecliptae. Ligustri Lucidi Fructus, Herba Ecliptae and their formulation have various hepatoprotective effects. There are many active ingredients in the formulation, such as triterpenes, iridoids, phenethyl alcohol-glucosides, coumarin ethers, etc. They can resist various chemistry-induced hepatic injury, ischemia reperfusion induced hepatic injury, and hepatic fibrosis. The mechanisms of hepatoprotective effect include anti-oxidative stress, anti-inflammatory, inhibition of hyperplasia and activation of liver stellate cell, motivating the apoptosis of liver stellate cell, influencing the metabolic processes of liver cell, ect. We reviewed and summarized the hepatoprotective effects of Erzhiwan and its components Ligustri Lucidi Fructus and Herba Ecliptae and explore the mechanisms of hepatoprotective effect in order to provide information for further research of pharmacodynamic material base.
  • [1] 闫冰,丁安伟,张丽.二至丸水提物对四氯化碳致小鼠急性肝损伤的保护作用[J].中国实验方剂学杂志,2010,16(14):131-134.
    [2] 袁继承,蒋永和,沈志滨.旱莲草化学成份的研究进展[J].亚太传统医药,2009,5(1):125-128.
    [3] 聂映,姚卫峰.二至丸不同极性部位对抗大鼠酒精性肝损伤的作用及机制[J].中国实验方剂学杂志,2014,20(20):145-149.
    [4] 蔡秀江,丁安伟,闫冰,等.二至丸保肝活性成分群对四氯化碳致小鼠急性肝损伤的保护作用[J].中国实验方剂学杂志,2011,17(20):145-148.
    [5] 闫冰,丁安伟,张丽.二至丸提取物对小鼠四氯化碳急性肝损伤的保护作用[J].中国中药杂志,2010,35(22):3080-3083.
    [6] 闫冰,李黎,陈星,等.二至丸的保肝活性部位群对四氯化碳致小鼠急性肝损伤的保护作用[J].中国实验方剂学杂志,2013,19(1):216-219.
    [7] 聂映,姚卫峰.二至丸对乙醇诱导的大鼠急性肝损伤的保护作用[J].中国实验方剂学杂志,2014,20(12):153-156.
    [8] 闫冰,丁安伟,张丽.二至丸对氧化性肝细胞损伤的保护作用研究[J].中国药房,2010,21(31):2886-2887.
    [9] 闫冰,丁安伟,张丽.二至丸水提物对体外肝细胞损伤的保护作用[J].药学实践杂志,2010,28(6):433-436.
    [10] 蔡秀江,闫冰,姚卫峰,等.二至丸保肝活性成分群对体外肝细胞损伤的保护作用[J].辽宁中医杂志,2012,39(2):212-215.
    [11] 闫冰,丁安伟,张丽.二至丸提取物对体外肝细胞损伤的保护作用[J].中国新药杂志,2010,19(21):1976-1979.
    [12] 蔡秀江,闫冰,姚卫峰,等.二至丸保肝活性成分群对体外肝细胞损伤的保护作用[J].中国药理学通报,2011,27(12):1774-1775.
    [13] 姚卫峰,蒋叶娟,蔡秀江,等.二至丸对四氯化碳致大鼠急性肝损伤血浆代谢组学研究[J].中国药学杂志,2013,48(10):808-813.
    [14] Yao WF,Gu HW,Zhu JJ,et al.Integrated plasma and urine metabolomics coupled with HPLC/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan[J].Anal Bioanal Chem,2014,406(28):7367-7378.
    [15] 陆小鸿.女贞子:肝肾护卫士[J].森林医学,2015,5:22-23.
    [16] Lin HM, Yen FL, Ng LT,et al.Protective effects of Ligustrum lucidum fruit extract on acute butylated hydroxytoluene-induced oxidative stress in rats[J].J Ethnopharmacol,2007,111(1):129-136.
    [17] 苏慧,李翔,李志毅,等.女贞子保肝作用机制的研究[J].华西药学杂志,2014,29(4):380-382.
    [18] 吕娟涛,汤浩.女贞子多糖对肝损伤保护作用的实验研究[J].中国医院药学杂志,2010,30(12):1024-1025.
    [19] 李阳,左燕,孙文基.女贞子中2种主要裂环环醚萜苷成分的分离鉴定及其抗氧化活性研究[J].中药材,2007,30(5):543-546.
    [20] 石变华,庄晓燕,白秀珍.墨旱莲水煎剂延缓肝脏衰老作用的研究[J].数理医药学杂志,2010,23(3):336-339.
    [21] 李春洋,白秀珍,程静,等.墨旱莲全草、茎、叶提取液对肝保护作用的研究[J].数理医药学杂志,2005,18(6):586-588.
    [22] 李春洋,白秀珍,杨学东.墨旱莲提取物对肝保护作用的影响[J].数理医药学杂志,2004,17(3):249-250.
    [23] 许静,陈杰,孙萍萍,等.蟛蜞菊内酯抗大鼠肝缺血再灌注损伤作用的研究[J].时珍国医国药,2014,25(9):2058-2059.
    [24] 徐汝明,邓克敏,陆阳.墨旱莲活性成分对刀豆蛋白A诱导的小鼠肝损伤的作用[J].上海交通大学学报,2010,30(1):50-54.
    [25] Xia YZ,Chen J,Cao Y,et al.Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2[J].Eur J Pharmacol,2013,714(1-3):105-111.
    [26] Lee MK, Ha NR, Yang H,et al.Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells[J].Phytomedicine,2008,15(9):775-780.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(4402) PDF downloads(777) Cited by()

Related
Proportional views

Research progress on hepatoprotective effects of Erzhiwan and its components

doi: 10.3969/j.issn.1006-0111.2016.04.001
  • 1. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;College of Life Science, Northwest University, Xi'an 710069, China
  • 2. No. 63 Troops, The Air Force of 94647, Fuzhou 350026, China
  • 3. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
  • 4. College of Life Science, Northwest University, Xi'an 710069, China
  • Received Date: 2015-08-28
  • Rev Recd Date: 2015-10-19

Abstract: Erzhiwan includes two components of Chinese herbal medicines-Ligustri Lucidi Fructus and Herba Ecliptae. Ligustri Lucidi Fructus, Herba Ecliptae and their formulation have various hepatoprotective effects. There are many active ingredients in the formulation, such as triterpenes, iridoids, phenethyl alcohol-glucosides, coumarin ethers, etc. They can resist various chemistry-induced hepatic injury, ischemia reperfusion induced hepatic injury, and hepatic fibrosis. The mechanisms of hepatoprotective effect include anti-oxidative stress, anti-inflammatory, inhibition of hyperplasia and activation of liver stellate cell, motivating the apoptosis of liver stellate cell, influencing the metabolic processes of liver cell, ect. We reviewed and summarized the hepatoprotective effects of Erzhiwan and its components Ligustri Lucidi Fructus and Herba Ecliptae and explore the mechanisms of hepatoprotective effect in order to provide information for further research of pharmacodynamic material base.

HU Dongmei, CHEN Xiaoling, LU Yang, FANG Minfeng, WANG Jingwen, WEN Aidong. Research progress on hepatoprotective effects of Erzhiwan and its components[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 289-291,296. doi: 10.3969/j.issn.1006-0111.2016.04.001
Citation: HU Dongmei, CHEN Xiaoling, LU Yang, FANG Minfeng, WANG Jingwen, WEN Aidong. Research progress on hepatoprotective effects of Erzhiwan and its components[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 289-291,296. doi: 10.3969/j.issn.1006-0111.2016.04.001
shu

    HTML

Reference (26)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return