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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 32-35,65

GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation: WANG Wei, CHENG Minghe, GAO Jing, ZHANG Xiaojie. Study on hemostasis of Bletillastriata hemostatic sponge[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 32-35,65. doi: 10.3969/j.issn.1006-0111.2016.01.009
shu

Study on hemostasis of Bletillastriata hemostatic sponge

doi: 10.3969/j.issn.1006-0111.2016.01.009
  • 1.

    No. 455 Hospital of PLA, Shanghai 200052, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    Medical Material Supply Station of Fengtai Warehouse, General Logistics Department of the PLA, Beijing 100071, China

  • Received Date: 2015-02-12
  • Rev Recd Date: 2015-06-02
  • Objective To investigate the hemostatic effect of Bletillastriata hemostatic sponge. Methods Tail hemorrhage model in rats was preparation. Another model was established in liver and spleen hemorrhagic model of rabbits, Beagle dog's abdominal aorta and liver were made. Hemostasis was performed with medical gauze, gelatin sponge and Bletillastriata hemostatic sponge. The hemostatic effects were evaluated by total blood loss, hemostatic time and histological observation. Observation of Bletillastriata hemostatic sponge change was completed to determine their degradation in the bodies. Results Rats tail hemorrhage was clamped, after 1 min, Bletillastriata hemostatic sponge could effectively stop the bleeding.The Bletillastriata hemostatic sponge has good hemostatic effect of rats tail hemorrhage model compared to blank group(P<0.01). Compare with the gelatin sponge group, the Bletillastriata hemostatic sponge could significantly shorten the liver and spleen bleeding time(P<0.05), decrease the volume of the spleen bleeding(P<0.05) and the liver bleeding(P<0.01), in hemorrhagic model of rabbits. Compared with the gelatin sponge group, Bletillastriata hemostatic sponge could more effectively stop the bleeding in the abdominal aorta and liver model of Beagle dogs (P<0.05). The Bletillastriata hemostatic sponge could be degraded in vivo. Histologic study revealed the Bletillastriata hemostatic sponge was no significant pathological change around the liver and spleen. Conclusion The Bletillastriata hemostatic sponge has good hemostatic effect. The hemostatic effect of Bletillastriata hemostatic sponge is better than gelatin sponge, which could be a good topical hemostatic material.
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    [2] 丁美丽,杜 智.可吸收止血材料的研究现状及临床应用[J].北京生物医学工程,2008,27(2):208-211.
    [3] 王 蕾,李武平,孙惠英,等.战伤急救止血技术新进展[J].解放军护理杂志,2007,24(12):45-46.
    [4] 陶阿丽,金耀东,刘金旗,等.中药白及化学成分、药理作用及临床应用研究进展[J].江苏农业科学,2013,41(11):6-9.
    [5] 王大太,郭树忠,张旭东,等.纤维蛋白胶干粉对兔肝创面的止血效果及应用剂量[J].中国康复理论与实践,2006,12(4):307-308.
    [6] 梁佩红,叶春婷,李斯明,等.复合I型胶原海绵创伤止血的动物实验研究[J].创伤外科杂志,2002,4(5):274-275.
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    [11] Michinori K,Noriko S,Miho Y,et al.Application studies of Rhizoma Bletillae(rhizomes of Bletilla striata)on atopicder-mastitis[J].Nat Med,2003,57(2):55-60.
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    [14] 仇树林,王 晓,李 兵,等.白芨胶载重组人表皮生长因子对创面表皮细胞DNA含量及周期的影响[J].中国组织工程研究与临床康复,2007,11(1):63-66.
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Study on hemostasis of Bletillastriata hemostatic sponge

doi: 10.3969/j.issn.1006-0111.2016.01.009
  • 1. No. 455 Hospital of PLA, Shanghai 200052, China
  • 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 3. Medical Material Supply Station of Fengtai Warehouse, General Logistics Department of the PLA, Beijing 100071, China
  • Received Date: 2015-02-12
  • Rev Recd Date: 2015-06-02

Abstract: Objective To investigate the hemostatic effect of Bletillastriata hemostatic sponge. Methods Tail hemorrhage model in rats was preparation. Another model was established in liver and spleen hemorrhagic model of rabbits, Beagle dog's abdominal aorta and liver were made. Hemostasis was performed with medical gauze, gelatin sponge and Bletillastriata hemostatic sponge. The hemostatic effects were evaluated by total blood loss, hemostatic time and histological observation. Observation of Bletillastriata hemostatic sponge change was completed to determine their degradation in the bodies. Results Rats tail hemorrhage was clamped, after 1 min, Bletillastriata hemostatic sponge could effectively stop the bleeding.The Bletillastriata hemostatic sponge has good hemostatic effect of rats tail hemorrhage model compared to blank group(P<0.01). Compare with the gelatin sponge group, the Bletillastriata hemostatic sponge could significantly shorten the liver and spleen bleeding time(P<0.05), decrease the volume of the spleen bleeding(P<0.05) and the liver bleeding(P<0.01), in hemorrhagic model of rabbits. Compared with the gelatin sponge group, Bletillastriata hemostatic sponge could more effectively stop the bleeding in the abdominal aorta and liver model of Beagle dogs (P<0.05). The Bletillastriata hemostatic sponge could be degraded in vivo. Histologic study revealed the Bletillastriata hemostatic sponge was no significant pathological change around the liver and spleen. Conclusion The Bletillastriata hemostatic sponge has good hemostatic effect. The hemostatic effect of Bletillastriata hemostatic sponge is better than gelatin sponge, which could be a good topical hemostatic material.

GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation: WANG Wei, CHENG Minghe, GAO Jing, ZHANG Xiaojie. Study on hemostasis of Bletillastriata hemostatic sponge[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 32-35,65. doi: 10.3969/j.issn.1006-0111.2016.01.009
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