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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(1): 1-4,8

ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
Citation: ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
shu

Research progress in the combined use of amphotericin B

doi: 10.3969/j.issn.1006-0111.2014.01.001

  • The Center of New Drug Development, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2013-03-12
  • Rev Recd Date: 2013-09-02
  • Objective Amphotericin B (AmB) was a polyene antifungal agent. Because of its lowest resistance rate and broad antibiotic spectrum, AmB was considered as a "gold standard" for the treatment of deep fungal infections. However, the occurrence of toxicity and serious side effects, especially renal toxicity, greatly limited the application of AmB in clinical antifungal therapy. Due to the lack of antifungal with high efficiency and low toxicity, the combination of antifungal agents with different mechanisms of action was a promising research direction. The advantage of the combinations was the course of treatment shortened, drug side effects reduced, the antibacterial spectrum expanded, and drug resistance avoided. The research progress in the combined use of AmB with different types of antifungal compounds were introduced in this article.
  • [1] Montoya JG,Rosso F. Is combination therapy indicated for invasive fungal infections?Yes and no[J].Curr Opin Infect Dis,2006,19(4):371-379.
    [2] Nivoix Y,Zamfir A,Lutun P,et al,Combination of caspofungin and an azole or an amphotericin B formulation in invasive fungal infections[J].J Infect,2006,52(1):67-74.
    [3] Kontoyiannis DP,Lewis RE.Combination chemotherapy for invasive fungal infections:what laboratory and clinical studies tell us so far[J].Drug Resist Updat,2003,6(1):257-269.
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    [10] Louie A, Kaw P, Banerjee P,et al. Impact of the order of initiation of fluconazole and amphotericin B in sequential or combination therapy on killing of Candida albicans in vitro and in a rabbit model of endocarditis and pyelonephritis[J].Antimicrob Agents Chemother, 2001, 45(2):485-494.
    [11] Samaranayake YH, Samaranayake LP, Yeung KW. Evaluation of polyene-azole antagonism in liquid cultures of Candida albicans using an automated turbidometric method[J].Chemotherapy, 2001, 47(4):279-291.
    [12] Barchiesi F, Schimizzi AM, Caselli F,et al. Interactions between triazoles and amphotericin B against Cryptococcus neoformans[J].Antimicrob Agents Chemother, 2000, 44(9):2435-2441.
    [13] Popp AI, White MH, Quadri T,et al. Amphotericin B with and without itraconazole for invasive aspergillosis. A three-year retrospective study[J].Int J Infect Dis, 1999, 3(3):157-160.
    [14] Ryder NS, Leitner I. Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species[J].MedMycol, 2001, 39(1):91-95.
    [15] Rodero L, Cordoba S, Cahn, P,et al. In vitro susceptibility studies of Cryptococcus Neoformans isolated from patients with no clinical response to amphotericin B therapy[J].J Antimicrob Chemother,2000, 45(2):239-242.
    [16] Perfect JR, Dismukes WE, Dromer F,et al. Clinical practice guidelines for the management of cryptococcal disease:2010 update by the infectious diseases society of america[J]. Clin Infect Dis, 2010,50(3):291-322.
    [17] Sevtap Arikan, Mario Lozano-Chiu,Victor Paetznick, et al.In vitro synergy of caspofungin and amphotericin B Against Aspergillus and Fusarium spp[J].Antimicrob Agents Chemother,2002, 46(1):245-247.
    [18] Jon AO, Adler-Moore JP, Smith PJ, et al. Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin[J]. Antimicrob Agents Chemother,2005, 49 (12):4895-4902.
    [19] Francesco B,Elisabetta S,Serena T, et al.Caspofungin in combination with amphotericin B against Candida parapsilosis[J]. Antimicrob Agents Chemoth, 2007, 51(3):941-945.
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    [21] Xu Y, Wang Y, Yan L, et al. Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans:endogenous ROS augmentation[J]. J Proteome Res,2009,8(11):5296-304.
    [22] An M, Shen H, Cao Y, et al.Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans[J]. Int J Antimicrob Agents. 2009; 33(3):258-63.
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Research progress in the combined use of amphotericin B

doi: 10.3969/j.issn.1006-0111.2014.01.001
  • The Center of New Drug Development, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2013-03-12
  • Rev Recd Date: 2013-09-02

Abstract: Objective Amphotericin B (AmB) was a polyene antifungal agent. Because of its lowest resistance rate and broad antibiotic spectrum, AmB was considered as a "gold standard" for the treatment of deep fungal infections. However, the occurrence of toxicity and serious side effects, especially renal toxicity, greatly limited the application of AmB in clinical antifungal therapy. Due to the lack of antifungal with high efficiency and low toxicity, the combination of antifungal agents with different mechanisms of action was a promising research direction. The advantage of the combinations was the course of treatment shortened, drug side effects reduced, the antibacterial spectrum expanded, and drug resistance avoided. The research progress in the combined use of AmB with different types of antifungal compounds were introduced in this article.

ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
Citation: ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
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