Effect of S-adenosylmethionine (SAM) on the treatment of chronic hepatitis B with hyperbilirubinemia
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摘要: 目的 观察腺苷蛋氨酸治疗慢性乙型肝炎伴胆红素升高的临床疗效及安全性。 方法 符合诊断标准的69例患者随机分为治疗组34例与对照组35例。治疗组采用注射用丁二磺酸腺苷蛋氨酸治疗,对照组采用苦黄注射液治疗,4周为1个疗程,比较两组疗效及安全性。 结果 治疗组总有效率为91.2%,疗效明显优于对照组的68.6% (P<0.05),且治疗后治疗组血清ALT、血清胆红素、TBA等肝功能指标改善程度明显优于对照组 (P<0.01);治疗组未发生药品不良反应,对照组发生3例药品不良反应。 结论 腺苷蛋氨酸治疗慢性乙型肝炎伴胆红素升高临床疗效及安全性优于苦黄。Abstract: Objective To evaluate the clinical efficiencies and safeties of S-adenosylmethionine (SAM) in treatment of 34 patients with chronic hepatitis B complicated hyperbilirubinemia. Methods Patients which meet the diagnostic criteria were randomized into the group with treatment of SAM (the treatment group, 34 cases) and the group with Kuhuang injection (the contrast group, 35 cases), 4 weeks for a course of treatment. The clinical efficacies and safeties were observed in the two groups. Results Compared with the contrast group, the overall efficiency was better in the treatment group (91.2% vs 68.6%, P<0.05), and the curative effects of serum ALT,serum bilirubin,TBA levels were better in the treatment group after treatment (P<0.01). There were no adverse drug reactions in the treatment group and 3 cases with adverse drug reactions in the contrast group. Conclusion The clinical efficiencies and safeties of SAM treatment in patients with chronic hepatitis B complicated hyperbilirubinemia were better than that of Kuhuang injection.
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Key words:
- chronic hepatitis B /
- hyperbilirubinemia /
- adenosylmethionine /
- Kuhuang injection
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