我院32例万古霉素血药浓度监测结果与临床疗效分析

陈淑敏; 田文园; 张杰; 边萌

doi:10.3969/j.issn.1006-0111.2013.03.012

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我院32例万古霉素血药浓度监测结果与临床疗效分析

陈淑敏, 田文园, 张杰, 边萌

文章导航 > 药学实践与服务 > 2013 > 31(3): 204-206,209

陈淑敏, 田文园, 张杰, 边萌. 我院32例万古霉素血药浓度监测结果与临床疗效分析[J]. 药学实践与服务, 2013, 31(3): 204-206,209. doi: 10.3969/j.issn.1006-0111.2013.03.012

引用本文:

CHENG Shu-min, TIAN Wen-yuan, ZHANG Jie, BIAN Meng. Clinical effects and blood concentration of vancomycin:32 cases report[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 204-206,209. doi: 10.3969/j.issn.1006-0111.2013.03.012

Citation:

CHENG Shu-min, TIAN Wen-yuan, ZHANG Jie, BIAN Meng. Clinical effects and blood concentration of vancomycin:32 cases report[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 204-206,209. doi: 10.3969/j.issn.1006-0111.2013.03.012

我院32例万古霉素血药浓度监测结果与临床疗效分析

doi: 10.3969/j.issn.1006-0111.2013.03.012

首都医科大学附属复兴医院, 北京 100038

Clinical effects and blood concentration of vancomycin:32 cases report

The Affiliated Fuxing Hospital of Shoudu Medical University, Beijing 100038 China

摘要: 目的评价我院32例患者万古霉素血药浓度监测结果与临床疗效分析,为临床合理用药提供参考。方法对我院2011年12月~2012年4月应用万古霉素并监测血药浓度的32例住院患者的临床资料(基础疾病、细菌学培养结果、用药情况、万古霉素血药谷浓度、疗效、肾功能情况等)进行统计、分析。结果细菌检出率53%,用药指征细菌学符合率31%。应用万古霉素的总有效率为69%,万古霉素血药浓度所测得谷值在10~20 mg/L范围内者占25%,治疗后肾功能异常发生率为13%。结论 32例应用万古霉素患者初次测得其血药浓度谷值在有效范围内的比例偏低,对老年患者需重视其血药浓度监测,并结合临床实际实现个体化给药。
- 万古霉素 /
- 血药浓度监测 /
- 临床疗效
Abstract: Objective To evaluate clinical utilization and blood concentration monitoring of vancomycin in our hospital and offer reference to reasonable clinical use of drugs. Methods The clinical information (primary diseases, bacteriological culture, blood concentration of vancomycin, clinical efficacy, renal function) of 32 inpatients who had been treated with vancomycin and their blood concentrations from Dec. 2011 to Apr. 2012 were analyzed statistically. Results The bacteria detection rate was 53%. The drug indications bacteriology coincidence rate was 31%. The total response rate of vancomycin was 68.75%. The valley values of 25% cases were between 10 mg/L and 20 mg/L. The incidence of renal dysfunction after treatment was 12.5%. Conclusion The valley value of blood concentration of the 32 cases using vancomycin that first measured were less in effective range which should be paid attention to the blood concentration monitoring of agedness patients to achieve an ideal individual administration according to clinical practice.
- vancomycin /
- blood concentration monitoring /
- clinical use of drugs

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[5]	Rybak M,Lomaestro B,Rotschafer JC,et al.Therapeutic monitoring of vancomycin in adult patients:a consensus review of the American Society of Health-System Pharmacists,the Infectious Diseases Society of America,and the Society of Infectious Diseases Pharmacists[J].Am J Health Syst pharm,2009,66:82.
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我院32例万古霉素血药浓度监测结果与临床疗效分析

doi: 10.3969/j.issn.1006-0111.2013.03.012

首都医科大学附属复兴医院, 北京 100038

收稿日期: 2012-07-02
修回日期: 2012-09-11

关键词:

万古霉素 /

血药浓度监测 /

临床疗效

摘要: 目的评价我院32例患者万古霉素血药浓度监测结果与临床疗效分析,为临床合理用药提供参考。方法对我院2011年12月~2012年4月应用万古霉素并监测血药浓度的32例住院患者的临床资料(基础疾病、细菌学培养结果、用药情况、万古霉素血药谷浓度、疗效、肾功能情况等)进行统计、分析。结果细菌检出率53%,用药指征细菌学符合率31%。应用万古霉素的总有效率为69%,万古霉素血药浓度所测得谷值在10~20 mg/L范围内者占25%,治疗后肾功能异常发生率为13%。结论 32例应用万古霉素患者初次测得其血药浓度谷值在有效范围内的比例偏低,对老年患者需重视其血药浓度监测,并结合临床实际实现个体化给药。