甲磺酸地拉韦啶解离常数及分配系数的测定
Determination of the dissociation constant and partition coefficient of mesylate delavirdine
-
摘要: 目的:测定甲磺酸地拉韦啶的解离常数和分配系数。方法:采用酸碱滴定法测定不同体积比的甲醇-水溶液中的药物pKa值,再外推至纯水中药物浓度无限稀释时的pKa值。采用HPLC法测定药物的分配系数。结果:甲磺酸地拉韦啶的pKa为4.635,1gP值为2.907。结论:甲磺酸地拉韦啶为弱酸性亲脂性药物。Abstract: Objective : To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods :The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results : The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively. Conclusions : mesylate delavirdine is a weak acid with lipophilic property.
-
Key words:
- mesylate delavirdine /
- ionization constant /
- partition coefficient /
- acid-base titration.
-
点击查看大图
计量
- 文章访问数: 2653
- HTML全文浏览量: 324
- PDF下载量: 50
- 被引次数: 0
下载:
