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Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes/issues, but are citable by Digital Object Identifier (DOI).
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, Available online , doi: 10.12206/j.issn.2097-2024.202412006
Abstract:
Objective To exploring the effects of nicotinamide mononucleotide （NMN） on hypertensive rats. Methods T wo rat hypertension models including hypertensive rats（SHR）and two-kidney two-clip （2K2C） rats were used to be given single, long-term or lifel...
, Available online , doi: 10.12206/j.issn.2097-2024.202405024
Abstract:
Objective To investigate the effect of midazolam on neuronal damage in ischemic stroke （IS） rats and its regulatory effect on PTEN-induced putative kinase 1 （PINK1）/E3 ubiquitin ligase （PARKIN） signaling pathway. Methods An IS rat model was est...
, Available online , doi: 10.12206/j.issn.2097-2024.202312012
Abstract:
Objective To explore the drug selection, usage, dosage and effect of clinical pharmacists in the treatment of secondary Candida bloodstream infection in patients with digestive tract perforation, and provide reference for rational clinical use of su...
, Available online , doi: 10.12206/j.issn.2097-2024.202409060
Abstract:
Objective To identify flavonoid glycosides with quorum sensing inhibitory activity from Epimedium brevicornum and evaluate their bioactivity. Methods The minimum inhibitory concentrations （MICs） of five major flavonoid glycosides （baohuoside, ...
, Available online , doi: 10.12206/j.issn.2097-2024.202404069
Abstract:
Objective The complex evolutionary history of the origin of medicinal blue herbs might result in the presence of adulterants, affecting the accuracy and safety of clinical medication. This study aims to provide a reference basis for the identificat...
, Available online , doi: 10.12206/j.issn.2097-2024.202407038
Abstract:
Objective To explore the promoting effect of long-term administration of nicotiflorin on the recovery of neurological function in rats with cerebral ischemia-reperfusion injury （CIRI）. Methods The CIRI model was established and nicotiflorin was ...
, Available online , doi: 10.12206/j.issn.2097-2024.202403059
Abstract:
Objective To establish the functional constipated mouse model by compound diphenoxylate, and explore the anti-constipation effect of black garlic polysaccharide. Methods Mouse small intestine ink propulsion experiment and mouse defecation ex...
, Available online , doi: 10.12206/j.issn.2097-2024.202406053
Abstract:
Sophora Flavescens is the dried root of the leguminous plant Sophora Flavescens Ait. It was first published in Shen Nong's Herbal Classic. Sophora Flavescens contains a variety of active ingredients, mainly including matrine and oxymatrine, with anti...
Sophora Flavescens is the dried root of the leguminous plant Sophora Flavescens Ait. It was first published in Shen Nong's Herbal Classic. Sophora Flavescens contains a variety of active ingredients, mainly including matrine and oxymatrine, with anti...
, Available online , doi: 10.12206/j.issn.2097-2024.202408045
Abstract:
The method of promoting blood circulation and removing blood stasis refers to the use of traditional Chinese medicine with a dispersing effect that can eliminate blood stasis in the body to treat the syndrome of blood stasis; It has the effects of un...
The method of promoting blood circulation and removing blood stasis refers to the use of traditional Chinese medicine with a dispersing effect that can eliminate blood stasis in the body to treat the syndrome of blood stasis; It has the effects of un...
, Available online , doi: 10.12206/j.issn.2097-2024.202410019
Abstract:
Objective To provide theoretical basis for the clinical application of the rational compatibility of C. odorata by studying the related domestic and international literature and exploring the properties of C. odorata according to the theory of Trad...
, Available online , doi: 10.12206/j.issn.2097-2024.202406035
Abstract:
Matrine is an alkaloid compound isolated and extracted from the traditional Chinese medicinal plant Sophora flavescens, which has anti-tumor, anti-inflammatory, and anti-viral effects. However, its clinical application has been limited due to its low...
Matrine is an alkaloid compound isolated and extracted from the traditional Chinese medicinal plant Sophora flavescens, which has anti-tumor, anti-inflammatory, and anti-viral effects. However, its clinical application has been limited due to its low...
, Available online , doi: 10.12206/j.issn.2097-2024.202404079
Abstract:
Acute lung injury （ALI） refers to the rapid onset of dyspnea, hypoxemia, and diffuse alveolar damage induced by various direct and indirect injurious factors, representing one of the clinically common diseases with a high mortality rate. However, the...
Acute lung injury （ALI） refers to the rapid onset of dyspnea, hypoxemia, and diffuse alveolar damage induced by various direct and indirect injurious factors, representing one of the clinically common diseases with a high mortality rate. However, the...
, Available online , doi: 10.12206/j.issn.2097-2024.202403004
Abstract:
Objective To investigate the disease characteristics and key points of pharmaceutical care in patients with inflammatory bowel disease and atrial fibrillation. Methods C linical pharmacist participated in the pharmaceutical practice process of a p...
, Available online , doi: 10.12206/j.issn.2097-2024.202408021
Abstract:
Hypertension is a systemic chronic vascular disease. From the perspective of Traditional Chinese Syndromes, hypertension belongs to the category of liver fire, vertigo, liver yang, headache and so on. Chinese medicine treatment of hypertension has gr...
Hypertension is a systemic chronic vascular disease. From the perspective of Traditional Chinese Syndromes, hypertension belongs to the category of liver fire, vertigo, liver yang, headache and so on. Chinese medicine treatment of hypertension has gr...
, Available online , doi: 10.12206/j.issn.2097-2024.202408046
Abstract:
Objective To compare the cost-effectiveness between Valproate and Levetiracetam in the treatment of childhood epilepsy and provide an economic basis for clinical medication choices. Methods A cost-effectiveness analysis was conducted using a de...
, Available online , doi: 10.12206/j.issn.2097-2024.202403014
Abstract:
Due to the diverse composition and complex physicochemical and biological characteristics, the pre-treatment of microbiological counting method （preparation of test solution） in microbiological limit test were interfered by many factors, which ultima...
Due to the diverse composition and complex physicochemical and biological characteristics, the pre-treatment of microbiological counting method （preparation of test solution） in microbiological limit test were interfered by many factors, which ultima...
, Available online , doi: 10.12206/j.issn.2097-2024.202404050
Abstract:
Objective To clarify the current development status and research hotspots in the field of experimental drug management in China through data mining by bibliometric. Method Ke y words such as “experiment”, “drug”, and “management” were used the sea...
, Available online , doi: 10.12206/j.issn.2097-2024.202405060
Abstract:
Radionuclides can be hazardous by absorbed through the skin, respiratory and digestive tracts. Chelating agents and adsorbents already could effectively remove them, however traditional chelators have side effects such as nephrotoxicity, teratogenici...
Radionuclides can be hazardous by absorbed through the skin, respiratory and digestive tracts. Chelating agents and adsorbents already could effectively remove them, however traditional chelators have side effects such as nephrotoxicity, teratogenici...
, Available online , doi: 10.12206/j.issn.2097-2024.202404077
Abstract:
Objective To explore the analytical methods combining multicolor flow cytometry with bioinformatics techniques for analyzing myeloid cells in the gastrocnemius of mice after muscle injury, and provide an experimental foundation for the study of musc...
Objective To explore the analytical methods combining multicolor flow cytometry with bioinformatics techniques for analyzing myeloid cells in the gastrocnemius of mice after muscle injury, and provide an experimental foundation for the study of musc...
, Available online , doi: 10.12206/j.issn.2097-2024.202407001
Abstract:
Objective To optimize the extraction, separation and purification process of actinoside E. Methods Single factor experiment combined with orthogonal test was used to determine the optimal extraction process of actinoside E using its content as ...
, Available online , doi: 10.12206/j.issn.2097-2024.202307014
Abstract:
Objective To explore the mechanism of Medicoscab tincture in the treatment of second-degree burns based on network pharmacology and molecular docking technology. Methods The effective components of the tincture were screened by the TCMSP; the e...
, Available online , doi: 10.12206/j.issn.2097-2024.202402020
Abstract:
Objective To explore the effects of CYP2C19, CYP2C9 and CYP3A5 genotypes on the plasma concentration of voriconazole in children. Methods C ollected blood samples from 50 hospitalized children with invasive fungal infections who received intraveno...
, Available online , doi: 10.12206/j.issn.2097-2024.202309014
Abstract:
Surface plasmonresonance （SPR） sensoris anoptical detection technique enables real-time and dynamic monitoring of biological samples. SPR-based biosensors have remarkable characteristics such as label-free detection and high sensitivity, making them ...
Surface plasmonresonance （SPR） sensoris anoptical detection technique enables real-time and dynamic monitoring of biological samples. SPR-based biosensors have remarkable characteristics such as label-free detection and high sensitivity, making them ...
, Available online , doi: 10.12206/j.issn.2097-2024.202306020
Abstract:
Objective To establish a central cutting two-dimensional liquid chromatography for the determination of lamotrigine in human plasma. Methods External standard method was used. The first dimensional chromatographic column: SNCB（T）-1A（silica gel, 4.6 m...
Objective To establish a central cutting two-dimensional liquid chromatography for the determination of lamotrigine in human plasma. Methods External standard method was used. The first dimensional chromatographic column: SNCB（T）-1A（silica gel, 4.6 m...
, Available online , doi: 10.12206/j.issn.2097-2024.202402028
Abstract:
It is difficult to treat malignant tumors, neurodegenerative diseases, and vascular diseases. For pathogenesis complexity of these diseases, researchers have focused on finding more drugs with high efficacy and low side effects. As a potential first-...
It is difficult to treat malignant tumors, neurodegenerative diseases, and vascular diseases. For pathogenesis complexity of these diseases, researchers have focused on finding more drugs with high efficacy and low side effects. As a potential first-...
, Available online , doi: 10.12206/j.issn.2097-2024.202308065
Abstract:
Piper nigrum L. is an evergreen climbing vine, which belongs to the genus Piperia in the Piperaceae family. Piper nigrum L., which known as the “king of spices”, is used as both food and medicine. The main active substances in Piper nigrum L. are alk...
Piper nigrum L. is an evergreen climbing vine, which belongs to the genus Piperia in the Piperaceae family. Piper nigrum L., which known as the “king of spices”, is used as both food and medicine. The main active substances in Piper nigrum L. are alk...
, Available online , doi: 10.12206/j.issn.2097-2024.202311021
Abstract:
Objective To investigate the effect of Triptolide on cerebral ischemia- reperfusion injury (CIRI) and explore its molecular mechanism. Methods O ne hundred and forty-four Wistar rats were randomly divided into sham operation group, model group, lo...
, Available online , doi: 10.12206/j.issn.2097-2024.202309040
Abstract:
Objective To analyze the effect of hypoproteinemia on the use of cefoperazone in patients, and provide references for the rational use of cefoperazone in clinical practice. Methods Clinical data of patients with cefoperazone blood concentration...
, Available online , doi: 10.12206/j.issn.2097-2024.202308034
Abstract:
Objective To observe the effect of Huoxin Pill (concentrated pill) combined with Baduanjin on the prognosis of patients with acute myocardial infarction complicated by Percutaneous Coronary Intervention (PCI). Methods 1 20 Patients with acute myoc...
, Available online , doi: 10.12206/j.issn.2097-2024.202204094
Abstract:
Objective To study the compliance and influencing factors of inhalation therapy in patients with stable chronic obstructive pulmonary disease (COPD),and carry out patient education and management accordingly. Methods COPD patients were selecte...
, Available online , doi: 10.12206/j.issn.2097-2024.202306028
Abstract:
Objective To analyze chemical constituents of compound Maxing Shigan decoction by ultra-high perfor-mance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Methods The separation was performed on a UPLC BEH C18 ...
, Available online , doi: 10.12206/j.issn.2097-2024.202208115
Abstract:
Objective To analyze the pharmacological mechanism of Shenling Baizhu powder in the treatment of cancer cachexia based on the network pharmacological method and provide a reference for the clinical application of classical traditional Chinese medi...
, Available online , doi: 10.12206/j.issn.2097-2024.202307034
Abstract:
Objective To investigate the potential mechanism of nicotinamide combined with amphotericin B against Candida albicans based on metabolomics. Methods T he intracellular metabolites of C. albicans intervened by different drugs including NAM, AmB, ...
, Available online , doi: 10.12206/j.issn.2097-2024.
Abstract:
, Available online , doi: 10.12206/j.issn.2097-2024.202309021
Abstract:
Lactic acid bacteria is a good candidate in living drug delivery system for its safety, beneficial nature, and intestinal colonizability. At present, most studies use it as a protein drug delivery carrier for disease treatment. As a model organism, a...
Lactic acid bacteria is a good candidate in living drug delivery system for its safety, beneficial nature, and intestinal colonizability. At present, most studies use it as a protein drug delivery carrier for disease treatment. As a model organism, a...
, Available online , doi: 10.12206/j.issn.2097-2024.202303006
Abstract:
Objective Study on the effect of Lishukang capsule on learning and memory impairment in mice with high altitude hypoxia based on Keap1/Nrf2/HO-1 signal pathway. Methods S ixty male Balb/C mice were randomly divided into normal control group, hypox...
, Available online , doi: 10.12206/j.issn.2097-2024.202112011
Abstract:
Objective To determine the content of five alkaloids from extracts of piper longum and test the pharmacodynamic effect of them on rats with experimental myocardial ischemia induced by injection of pituitrin. Methods T he content of five alkaloids ...
, Available online , doi: 10.12206/j.issn.2097-2024.202404041
Abstract:
Objective To analyze the characteristics of adverse drug reactions （ADR） reported in Sixth People’s Hospital South Campus, Shanghai Jiaotong University from 2021 to 2023, to provide reference for promoting rational clinical drug use. Methods AD...
, Available online , doi: 10.12206/j.issn.2097-2024.202409007
Abstract:
Traditional Chinese medicine contains a variety of volatile components（VOCs）such as terpenes and aliphatics, which have significant pharmacological activities, and are commonly analyzed by gas chromatography（GC）and gas chromatography-mass spectrometr...
Traditional Chinese medicine contains a variety of volatile components（VOCs）such as terpenes and aliphatics, which have significant pharmacological activities, and are commonly analyzed by gas chromatography（GC）and gas chromatography-mass spectrometr...
, Available online , doi: 10.12206/j.issn.2097-2024.202412058
Abstract:
Perilla is an annual herbaceous plant with edible and medicinal value belonging to the Lamiaceae family. It has a long history of cultivation and use. The volatile oil is one of its main active components in perilla leaves, and Perilla aldehyde is it...
Perilla is an annual herbaceous plant with edible and medicinal value belonging to the Lamiaceae family. It has a long history of cultivation and use. The volatile oil is one of its main active components in perilla leaves, and Perilla aldehyde is it...
, Available online , doi: 10.12206/j.issn.2097-2024.202409055
Abstract:
Objective To investigate the effect of spontaneous hypertension on the remodeling of cardiac and aortic tissues in rats, with special attention to the changes in the content of collagen fibers, elastic fibers and secreted Frizzled-related protein 2...
, Available online , doi: 10.12206/j.issn.2097-2024.202401072
Abstract:
Objective To establish a method for rapid detection of tramadol in urine by liquid-liquid extraction（LLE）-surface-enhanced Raman spectroscopy （SERS）. Methods Tramadol was extracted from urine with chloroform∶isopropyl alcohol （9∶1） extractant ...
, Available online , doi: 10.12206/j.issn.2097-2024.202404059
Abstract:
Objective To establish a HPLC method for determining thimerosal compounds in eye drops. Methods A gradient HPLC system was used in the quantitative analysis of thimerosal compounds on Shiseido MGII C18 column （4.6 mm×250 mm, 5 μm）, using 1% triet...
, Available online , doi: 10.12206/j.issn.2097-2024.202406029
Abstract:
Objective To investigate the preventive and therapeutic effects of ethanol extracts derived from three sources of traditional Chinese medicine: Stellera chamaejasme L., Euphorbia fischeriana Steud., and Euphorbia kansuensis Prokh., on imiquimod （IMQ...
, Available online , doi: 10.12206/j.issn.2097-2024.202310021
Abstract:
Objective To establish quality evaluation method of Andrographis paniculata standard decoction by UPLC. Methods 21 batches of Andrographis paniculata standard decoctions were prepared according to the standardization method of TCM decoction pi...
, Available online , doi: 10.12206/j.issn.2097-2024.202404093
Abstract:
Objective To compare the effecacy of colistin sulphate with cefoperazone and sulbactam in the treatment of pan-resistant Acinetobacter baumannii with the combination therapy of tigecycline with cefoperazone and baubactam. Methods B y retrospective...
, Available online , doi: 10.12206/j.issn.2097-2024.202407040
Abstract:
Objective Analyze the supply situation of pharmaceutical markets in some regions of Africa, providing medical information references for Chinese enterprises and citizens entering Africa for their business and their life. Methods A comparative ana...
, Available online , doi: 10.12206/j.issn.2097-2024.202402034
Abstract:
Objective To analyze the effectiveness of reasonable control measures for prophylactic use of antibiotics for urinary system lithotripsy. Methods By antimicrobial stewardship, strengthening special comments on antibiotics and information not...
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