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NIU Chong, LIU Gui-hua, ZHANG Zhong-hu. Progress on the impurities in Oxaliplatin[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 412-414,436. doi: 10.3969/j.issn.1006-0111.2012.06.004
Citation: NIU Chong, LIU Gui-hua, ZHANG Zhong-hu. Progress on the impurities in Oxaliplatin[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 412-414,436. doi: 10.3969/j.issn.1006-0111.2012.06.004

Progress on the impurities in Oxaliplatin

doi: 10.3969/j.issn.1006-0111.2012.06.004
  • Received Date: 2011-09-09
  • Rev Recd Date: 2012-05-09
  • The research progress on the preparation and impurities of Oxaliplatin were summarized based on the recent documents, which generalize the impurity organization, impurity controlling and preparation stability. The principal impurities in Oxaliplatin were oxalic acid, impurity B, impurity C, impurity D and impurity E. All of the impurities were produced during the syntheses and also could be degraded from Oxaliplatin and its preparation. The impurities in Oxaliplatin and its preparation must be controlled respectively to ensure the security and effect of the drugs.
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Progress on the impurities in Oxaliplatin

doi: 10.3969/j.issn.1006-0111.2012.06.004

Abstract: The research progress on the preparation and impurities of Oxaliplatin were summarized based on the recent documents, which generalize the impurity organization, impurity controlling and preparation stability. The principal impurities in Oxaliplatin were oxalic acid, impurity B, impurity C, impurity D and impurity E. All of the impurities were produced during the syntheses and also could be degraded from Oxaliplatin and its preparation. The impurities in Oxaliplatin and its preparation must be controlled respectively to ensure the security and effect of the drugs.

NIU Chong, LIU Gui-hua, ZHANG Zhong-hu. Progress on the impurities in Oxaliplatin[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 412-414,436. doi: 10.3969/j.issn.1006-0111.2012.06.004
Citation: NIU Chong, LIU Gui-hua, ZHANG Zhong-hu. Progress on the impurities in Oxaliplatin[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 412-414,436. doi: 10.3969/j.issn.1006-0111.2012.06.004
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