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肝脏缺血再灌注损伤发生机制及药物干预研究进展

倪敏 沈甫明

倪敏, 沈甫明. 肝脏缺血再灌注损伤发生机制及药物干预研究进展[J]. 药学实践与服务, 2011, 29(3): 179-180,211.
引用本文: 倪敏, 沈甫明. 肝脏缺血再灌注损伤发生机制及药物干预研究进展[J]. 药学实践与服务, 2011, 29(3): 179-180,211.
NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.
Citation: NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.

肝脏缺血再灌注损伤发生机制及药物干预研究进展

Advances in the mechanism and medication cure ways of ischemia-reperfusion injury

  • 摘要: 缺血再灌注损伤是许多因子参与的复杂的病理生理过程,是影响肝移植、肝脏叶段切除术后肝功能的一个多因素过程。本文主要阐述肝脏缺血再灌注损伤的发病机制及药物预处理对其的防治。
  • [1] Banga NR,Homer-Vanniasinkam S,Graham A,et al.Ischemic preconditioning in transplantation and major resection of the liver[J].Br J Surg,2005,92(5):528. [2] Zeng Z,Huang HF,et al. Heme oxygenase-1 protects donor livers from ischemia/reperfusion injury:the role of Kupffer cells[J].World J Gastroenterol, 2010 Mar 14,16(10):1285. [3] Zhou W,Zhang Y,Hosch MS.Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion[J].Hepatology,2001,33(4):902. [4] Tsuchiya Y,Suzuki S,Inaba K,et al.Impact of endothelin-1 on microcirculatory disturbance after partial hepatectomy under ischemia/reperfusion in thioacetamide-induced cirrhotic rats[J].J Surg Res,2003,111(1):100. [5] Liu PG,He SQ,Wu Jian,et al.Protective effects of apocynin and allopurinol on ischemia/reperfusion induced liver injury in mice[J].World J Gastroenterol,2008, 14(18):2832. [6] Liu JN,Zhang JX,Zhang XL,et al.The effect of oxidative stress in myocardial cell injury in mice exposed to chronic intermittent hypoxia[J].Chin Med J(Engl),2010,123(1):74. [7] Wang NT, Lin HI. Effects of the antioxidants lycium barbarum and ascorbic acid on reperfusion liver injury in rats[J].Transplant Proc,2009,41(10):4110 [8] Glanemann M,Vollmar B,Nussler AK,et al.Ischemic preconditioning protects from hepatic ischemia/reperfusion injury by preservation of microcirculation and mitochondria redox-state[J].J Hepatol,2003,38(1):59. [9] Malhi H,Gores GJ,Lemasters JJ,et al.Apoptosis and necrosis in the liver:a tale of two deaths[J].Hepatology,2006,43(2 Suppl 1):831.[10] 张厚忠,韩喜春,姜伟栋.谷胱甘肽和缺血预处理对大鼠肝脏缺血再灌注损伤的影响[J].中国老年学杂志,2006,26(10):91.[11] 马兴久,耿振宏,李德春,等.乌司他汀对肝脏缺血-再灌注损伤的防护作用[J].医师进修杂志,2005,28(7):22.[12] 黄 博,陈高飞,陈国勇,等.茶多酚对大鼠肝脏缺血-灌注损伤的保护作用[J].胃肠病学和肝病学杂志,2006,15(5):522.[13] 林胜璋,余耀军,游 涛,等.大黄素对大鼠肝脏缺血再灌注损伤的预防作用[J].中国中西医结合外科杂志,2006,12(12):136.[14] 赵 珂.银杏叶提取物对大鼠肝脏缺血再灌注损伤的保护作用[J].中原医刊,2007,34 (3):5.[15] Ke QH,Zheng SS,Liang TB,et al.Pre-treatment of hypertonic saline can increase endogenous interleukin 10 release to attenuate hepatic ischemia reperfusion injury[J].Dig Dis Sc,2006,51:2257.[16] Gonzalez EA,Kozar RA,Suliburk JW,et al. Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion[J].J Trauma,2006,61(1):66.[17] Elahe T Crockett,James J Galligan,et al.Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists[J].BMC Clinical Pathology,2006,15:6. [18] Wang DW,Zhou RB,Yao YM.Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases[J].Chin J Traumatol,2009 Dec,12(6):355.[19] Liu C,Shen FM,Su DF,et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor[J].Crit Care Med,2009,37(2):634.[20] Parrish WR,Rosas-Ballina M,Pavlov VA,et al.Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling[J].Mol Med,2008,14(9-10):567.[21] 孟兴凯,史留斌,彭淑牖,等.山莨菪碱抗肝脏缺血再灌注损伤的实验研究[J].中国急救医学,2001,21(1):4.[22] 黄 韧.山茛菪碱对大鼠供肝热缺血再灌注损伤的保护作用[J].临床和实验医学杂志,2009,8(1):17.
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  • 收稿日期:  2010-03-19
  • 修回日期:  2011-02-28

肝脏缺血再灌注损伤发生机制及药物干预研究进展

摘要: 缺血再灌注损伤是许多因子参与的复杂的病理生理过程,是影响肝移植、肝脏叶段切除术后肝功能的一个多因素过程。本文主要阐述肝脏缺血再灌注损伤的发病机制及药物预处理对其的防治。

English Abstract

倪敏, 沈甫明. 肝脏缺血再灌注损伤发生机制及药物干预研究进展[J]. 药学实践与服务, 2011, 29(3): 179-180,211.
引用本文: 倪敏, 沈甫明. 肝脏缺血再灌注损伤发生机制及药物干预研究进展[J]. 药学实践与服务, 2011, 29(3): 179-180,211.
NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.
Citation: NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.
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