Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 6
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(6): 418-421,425

DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
Citation: DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
shu

Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion

  • 1.

    Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China;Department of Pharmacy,Shanghai Public Health Clinical Center,Shanghai 201508,China

  • 2.

    Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China

  • Received Date: 2010-03-30
  • Rev Recd Date: 2010-05-07
  • Objective To prepare Piroxicam microemulsion and investigate its transdermal characteristics in vitro. Methods The o/w microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase,Labrasol and Cremophor EL as surfactants,Transcutol P and Ethanol as cosurfactants according to the pseudo-ternary phase diagrams.The transdermal characteristics were evaluated by modified Franz diffusion cell method.Rat's skin was used as permeation barrier and the drug concentration was measured by HPLC. Results The optimum formulation consisted of 0.5%Piroxicam,10%Lauroglycol FCC,50%water,13.3%Labrasol,Cremophor El and Transcutol P.The permeation rate of Piroxicam was 10.04±1.73 μg/(cm2·h). Conclusion The Results indicated that the optimum microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of Piroxicam.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2657) PDF downloads(609) Cited by()

Related
Proportional views

Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion

  • 1. Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China;Department of Pharmacy,Shanghai Public Health Clinical Center,Shanghai 201508,China
  • 2. Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China
  • Received Date: 2010-03-30
  • Rev Recd Date: 2010-05-07

Abstract: Objective To prepare Piroxicam microemulsion and investigate its transdermal characteristics in vitro. Methods The o/w microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase,Labrasol and Cremophor EL as surfactants,Transcutol P and Ethanol as cosurfactants according to the pseudo-ternary phase diagrams.The transdermal characteristics were evaluated by modified Franz diffusion cell method.Rat's skin was used as permeation barrier and the drug concentration was measured by HPLC. Results The optimum formulation consisted of 0.5%Piroxicam,10%Lauroglycol FCC,50%water,13.3%Labrasol,Cremophor El and Transcutol P.The permeation rate of Piroxicam was 10.04±1.73 μg/(cm2·h). Conclusion The Results indicated that the optimum microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of Piroxicam.

DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
Citation: DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return