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Volume 28 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 220-222

YE Li, ZHU De-qiu, YE Xian-cheng. The protective effect of wikstromol on cultured cortical neurons induced by H2O2 and excitatory neurotransmitter[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 189-192.
Citation: ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou. Synthesis and anoxia endurance activity of thiadiazole derivatives[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 220-222.
shu

Synthesis and anoxia endurance activity of thiadiazole derivatives

  • 1.

    Department of Medicinal Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • 2.

    Center for New Drug Evaluation,Faculty of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2009-11-25
  • Rev Recd Date: 2010-02-22
  • Objective To design and synthesize novel thiadiazole derivatives and evaluate their anoxia endurance activity. Methods Beginning with thiosemicarbazide,title compounds were synthesized in three steps,then the anoxia endurance activity was evaluated. Results and Conclusion Seven novel thiadiazole derivatives were synthesized and their anoxia endurance activity was evaluated.One of the title compounds exhibited the same anoxia endurance activity as that of acetazolamide,which can be used as the lead for further study.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Synthesis and anoxia endurance activity of thiadiazole derivatives

  • 1. Department of Medicinal Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • 2. Center for New Drug Evaluation,Faculty of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2009-11-25
  • Rev Recd Date: 2010-02-22

Abstract: Objective To design and synthesize novel thiadiazole derivatives and evaluate their anoxia endurance activity. Methods Beginning with thiosemicarbazide,title compounds were synthesized in three steps,then the anoxia endurance activity was evaluated. Results and Conclusion Seven novel thiadiazole derivatives were synthesized and their anoxia endurance activity was evaluated.One of the title compounds exhibited the same anoxia endurance activity as that of acetazolamide,which can be used as the lead for further study.

YE Li, ZHU De-qiu, YE Xian-cheng. The protective effect of wikstromol on cultured cortical neurons induced by H2O2 and excitatory neurotransmitter[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 189-192.
Citation: ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou, ZHU Zhan-zhou. Synthesis and anoxia endurance activity of thiadiazole derivatives[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 220-222.
shu

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