Synthesis of hairpin-polyamides containing β-alanine

Key words: 
• β-alanine /
• polyamide /
• N-methyl Pyrrole /
• N-methyl imidazole,synthesis /

Abstract: Objective To develop a new method and strategy for the synthesis of hairpin-polyamides containingβ-alanine. Methods The hairpin-polyamides were synthesized by the HOBT/DCC coupling reaction in good yields through the optimization of hydrogenation of nitro group and the 2+2 fragment coupling strategy. Results A hairpin-polyamide NO₂ImPyβImPyγImPyβPyPyβCOOC₂H₂ was synthesized successfully with good yield. Conclusion The hairpin-polyamides containing β-alanine in the molecular can be easily and efficiently synthesized through the optimization of reaction temperature,solvent and fragment coupling strategy.