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Volume 28 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 215-216,240

ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
Citation: ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
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The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone

  • School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China

  • Received Date: 2009-11-18
  • Rev Recd Date: 2010-01-23
  • Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone. Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram. Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times. Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins.
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    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 84.4 %FULLTEXT: 84.4 %META: 7.9 %META: 7.9 %PDF: 7.7 %PDF: 7.7 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 30.2 %其他: 30.2 %China: 0.2 %China: 0.2 %Korea Republic of: 0.2 %Korea Republic of: 0.2 %三明: 0.2 %三明: 0.2 %上海: 1.3 %上海: 1.3 %丽水: 0.2 %丽水: 0.2 %北京: 23.1 %北京: 23.1 %台州: 0.2 %台州: 0.2 %天津: 0.2 %天津: 0.2 %成都: 0.3 %成都: 0.3 %杭州: 1.7 %杭州: 1.7 %武汉: 0.5 %武汉: 0.5 %沈阳: 0.3 %沈阳: 0.3 %济南: 0.2 %济南: 0.2 %深圳: 0.3 %深圳: 0.3 %湖州: 0.2 %湖州: 0.2 %澳大利亚新南威尔士悉尼: 0.3 %澳大利亚新南威尔士悉尼: 0.3 %玉溪: 0.3 %玉溪: 0.3 %珀斯: 0.7 %珀斯: 0.7 %珠海: 0.2 %珠海: 0.2 %芒廷维尤: 9.4 %芒廷维尤: 9.4 %蚌埠: 0.2 %蚌埠: 0.2 %西宁: 26.6 %西宁: 26.6 %西安: 0.2 %西安: 0.2 %贵阳: 1.2 %贵阳: 1.2 %运城: 0.2 %运城: 0.2 %郑州: 0.2 %郑州: 0.2 %金华: 0.3 %金华: 0.3 %长沙: 0.8 %长沙: 0.8 %青岛: 0.3 %青岛: 0.3 %其他ChinaKorea Republic of三明上海丽水北京台州天津成都杭州武汉沈阳济南深圳湖州澳大利亚新南威尔士悉尼玉溪珀斯珠海芒廷维尤蚌埠西宁西安贵阳运城郑州金华长沙青岛Highcharts.com
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The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone

  • School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China
  • Received Date: 2009-11-18
  • Rev Recd Date: 2010-01-23

Abstract: Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone. Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram. Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times. Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins.

ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
Citation: ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
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