Determination of residual organic solvents in orlistat by headspace gas chromatography

Key words: 
• headspace gas chromatography /
• orlistat /
• residual organic solvents

Abstract: Objective To establish a method for determination of four residual organic solvents in orlistat. Methods The residual organic solvents in orlistat are hexane、heptane、methanol and acetonitril.They were quantitatively determined by headspace gas chromatography(GC) on HP-INNOWAX column with FID detector,nitrogen as the carries. Results Four residual solvents were completely separated.There was a good linearity in the experimental concentration(r=0.999 0～0.999 3).The RSD of precision was less than 10%.The average recovery rate ranged from 97.1% to 101.9%.The detection limits was between 0.009～1.833 μg/ml. Conclusion The method proves to be rapid,sensitive and accurate.It can be used for quality control for the determination of four residual organic solvents in orlistat.