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Volume 28 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 184-185,208

MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
Citation: MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
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Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules

  • Departhment of pharmacy,85th Hospital of PLA,Shanghai 200052,China

  • Received Date: 2010-01-15
  • Rev Recd Date: 2010-02-22
  • Objective To prepare the andrographolide self-emulsifying drug delivery soft capsules(ASESC) and evaluate its quality. Methods The andrographolide self-emulsifying soft capsules were prepared.To screen the dissolution of andrographolide,the dissolution media and dissolution method of Ch.P were analysied.The dissolution of SMESC was measured,taking the commercial capsule as reference. Results The self-emulsifying drug delivery system was composed of ethyl oleate(10%),Tween 80(54%),n-Butanol(36%).The percent of accumulated dissolution of andrographolide in self-emulsifying drug delivery soft capsules in 0.2% SDS fluid was up to 70% at 45 min,which was far more than the commercial capsule. Conclusion The andrographolide self-emulsifying drug delivery capsules has been successfully prepared,and the dissolution of andrographolide was remarkably improved.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 30.2 %其他: 30.2 %China: 0.2 %China: 0.2 %Korea Republic of: 0.2 %Korea Republic of: 0.2 %三明: 0.2 %三明: 0.2 %上海: 1.3 %上海: 1.3 %丽水: 0.2 %丽水: 0.2 %北京: 23.1 %北京: 23.1 %台州: 0.2 %台州: 0.2 %天津: 0.2 %天津: 0.2 %成都: 0.3 %成都: 0.3 %杭州: 1.7 %杭州: 1.7 %武汉: 0.5 %武汉: 0.5 %沈阳: 0.3 %沈阳: 0.3 %济南: 0.2 %济南: 0.2 %深圳: 0.3 %深圳: 0.3 %湖州: 0.2 %湖州: 0.2 %澳大利亚新南威尔士悉尼: 0.3 %澳大利亚新南威尔士悉尼: 0.3 %玉溪: 0.3 %玉溪: 0.3 %珀斯: 0.7 %珀斯: 0.7 %珠海: 0.2 %珠海: 0.2 %芒廷维尤: 9.4 %芒廷维尤: 9.4 %蚌埠: 0.2 %蚌埠: 0.2 %西宁: 26.6 %西宁: 26.6 %西安: 0.2 %西安: 0.2 %贵阳: 1.2 %贵阳: 1.2 %运城: 0.2 %运城: 0.2 %郑州: 0.2 %郑州: 0.2 %金华: 0.3 %金华: 0.3 %长沙: 0.8 %长沙: 0.8 %青岛: 0.3 %青岛: 0.3 %其他ChinaKorea Republic of三明上海丽水北京台州天津成都杭州武汉沈阳济南深圳湖州澳大利亚新南威尔士悉尼玉溪珀斯珠海芒廷维尤蚌埠西宁西安贵阳运城郑州金华长沙青岛Highcharts.com
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Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules

  • Departhment of pharmacy,85th Hospital of PLA,Shanghai 200052,China
  • Received Date: 2010-01-15
  • Rev Recd Date: 2010-02-22

Abstract: Objective To prepare the andrographolide self-emulsifying drug delivery soft capsules(ASESC) and evaluate its quality. Methods The andrographolide self-emulsifying soft capsules were prepared.To screen the dissolution of andrographolide,the dissolution media and dissolution method of Ch.P were analysied.The dissolution of SMESC was measured,taking the commercial capsule as reference. Results The self-emulsifying drug delivery system was composed of ethyl oleate(10%),Tween 80(54%),n-Butanol(36%).The percent of accumulated dissolution of andrographolide in self-emulsifying drug delivery soft capsules in 0.2% SDS fluid was up to 70% at 45 min,which was far more than the commercial capsule. Conclusion The andrographolide self-emulsifying drug delivery capsules has been successfully prepared,and the dissolution of andrographolide was remarkably improved.

MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
Citation: MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
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