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Volume 27 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(6): 448-450

ZHU Zhan-zhou, DOU Jia-tai, XU Wei-heng, JI Da-wei, WANG Xiao-yan, HE Bang-ping, SUN Qing-yan. Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 448-450.
Citation: ZHU Zhan-zhou, DOU Jia-tai, XU Wei-heng, JI Da-wei, WANG Xiao-yan, HE Bang-ping, SUN Qing-yan. Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 448-450.
shu

Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid

  • 1.

    14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China

  • 2.

    College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-05-05
  • Objective :To explore an easily-controled,environmentally-benign synthetic method of coumarin derivatives. Methods :Several coumarin derivatives are synthesized from phenols and ethyl acetoacetates by the Pechmann reaction under four different conditions(H2SO4,BiCl3,Microwave/BiCl3,Microwave/ionic liquid). Results :Compared with traditional reaction,present method under microwave and ionic liquid avoids using of organic solvent,shorten the reaction period and obtain a good yield. Conclusion :Microwave accelerated Pechmann reaction using ionic liquid as catalyst is a convenient and green alternative for synthesizing coumarin derivatives.
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Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid

  • 1. 14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China
  • 2. College of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-05-05

Abstract: Objective :To explore an easily-controled,environmentally-benign synthetic method of coumarin derivatives. Methods :Several coumarin derivatives are synthesized from phenols and ethyl acetoacetates by the Pechmann reaction under four different conditions(H2SO4,BiCl3,Microwave/BiCl3,Microwave/ionic liquid). Results :Compared with traditional reaction,present method under microwave and ionic liquid avoids using of organic solvent,shorten the reaction period and obtain a good yield. Conclusion :Microwave accelerated Pechmann reaction using ionic liquid as catalyst is a convenient and green alternative for synthesizing coumarin derivatives.

ZHU Zhan-zhou, DOU Jia-tai, XU Wei-heng, JI Da-wei, WANG Xiao-yan, HE Bang-ping, SUN Qing-yan. Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 448-450.
Citation: ZHU Zhan-zhou, DOU Jia-tai, XU Wei-heng, JI Da-wei, WANG Xiao-yan, HE Bang-ping, SUN Qing-yan. Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 448-450.
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