Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury

Key words: 
• Ginkgo biloba /
• Rose roxburghii /
• anti-oxidation activities /
• Ginkgolic acids

Abstract: Objective :To study the protective effect of compound Ginkgo biloba(CGB) on hepatic injury. Methods :Animal model of chemical hepatic injury was established by ip CC₁₄ in mice,the content of ALT,AST in rats′ serum,the content of MDA and the activity of SOD in liver homogenate were assayed after intragastric administration 30 days in mices with Ginkgo biloba extracts(GBE)、compound ginkgo biloba(CGB).The model of human normal hepatocyte L-02 induced by H₂O₂ was prepared,determining the level of total antioxidant capacity in serum(TAOC),and the proliferation of hepatocyte L-02 using MTT. Results :The content of AST,ALT in rats′ serum levels in groups of CGB(2.4、0.8 g/kg) decreased significantly(P<0.01,P<0.05),the activity of SOD increased singnificantly and the MDA levels decreased obviously in liver homogenate of mices.The CGB can remarkably increase the level of TAOC and the proliferation of liver cell L-02. Conclusion :CGB are better than GBE in protecting chemical liver injury.