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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(6): 437-438,444

PAN Su-hua, NIU Wen-min, WU li, YU Rui-lian. Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 437-438,444.
Citation: PAN Su-hua, NIU Wen-min, WU li, YU Rui-lian. Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 437-438,444.
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Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury

  • School of pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China

  • Received Date: 2009-09-20
  • Objective :To study the protective effect of compound Ginkgo biloba(CGB) on hepatic injury. Methods :Animal model of chemical hepatic injury was established by ip CC14 in mice,the content of ALT,AST in rats′ serum,the content of MDA and the activity of SOD in liver homogenate were assayed after intragastric administration 30 days in mices with Ginkgo biloba extracts(GBE)、compound ginkgo biloba(CGB).The model of human normal hepatocyte L-02 induced by H2O2 was prepared,determining the level of total antioxidant capacity in serum(TAOC),and the proliferation of hepatocyte L-02 using MTT. Results :The content of AST,ALT in rats′ serum levels in groups of CGB(2.4、0.8 g/kg) decreased significantly(P<0.01,P<0.05),the activity of SOD increased singnificantly and the MDA levels decreased obviously in liver homogenate of mices.The CGB can remarkably increase the level of TAOC and the proliferation of liver cell L-02. Conclusion :CGB are better than GBE in protecting chemical liver injury.
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Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury

  • School of pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China
  • Received Date: 2009-09-20

Abstract: Objective :To study the protective effect of compound Ginkgo biloba(CGB) on hepatic injury. Methods :Animal model of chemical hepatic injury was established by ip CC14 in mice,the content of ALT,AST in rats′ serum,the content of MDA and the activity of SOD in liver homogenate were assayed after intragastric administration 30 days in mices with Ginkgo biloba extracts(GBE)、compound ginkgo biloba(CGB).The model of human normal hepatocyte L-02 induced by H2O2 was prepared,determining the level of total antioxidant capacity in serum(TAOC),and the proliferation of hepatocyte L-02 using MTT. Results :The content of AST,ALT in rats′ serum levels in groups of CGB(2.4、0.8 g/kg) decreased significantly(P<0.01,P<0.05),the activity of SOD increased singnificantly and the MDA levels decreased obviously in liver homogenate of mices.The CGB can remarkably increase the level of TAOC and the proliferation of liver cell L-02. Conclusion :CGB are better than GBE in protecting chemical liver injury.

PAN Su-hua, NIU Wen-min, WU li, YU Rui-lian. Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 437-438,444.
Citation: PAN Su-hua, NIU Wen-min, WU li, YU Rui-lian. Effects of compatibility program of Ginkgo biloba extracts and Rosa roxburghii on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 437-438,444.
shu

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