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Volume 27 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(3): 193-194,200

GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.
Citation: GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.
shu

Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers

  • Department of Pharmacy, Changzheng Hospital, Second military medical university, Shanghai 200003, China

  • Received Date: 2008-12-25
  • Objective :To study the pharmacokinetics of minocycline hydrochloride in 10 Chinese healthy volunteers after a single intravenous administration of 200mg minocycline. Methods :Minocycline hydrochloride concentration in plasma was measured by an improved HPLC method,and the pharmacokinetic parameters were calculated. Results :After single dose administration of 200 mg minocycline,the main pharmacokinetic parameters t1/2,Cmax,tmax,AUC0→72h,AUC0→∞were(18.1±4.07) h,(4.744±0.887) mg/L,2.0 h,(75.71 ±10.68) mg·h/L,(79.90±12.81) mg·h/L,respectively. Conclusion :The main pharmacokinetic parameters of minocycline are consistent with those reported previously.
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Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers

  • Department of Pharmacy, Changzheng Hospital, Second military medical university, Shanghai 200003, China
  • Received Date: 2008-12-25

Abstract: Objective :To study the pharmacokinetics of minocycline hydrochloride in 10 Chinese healthy volunteers after a single intravenous administration of 200mg minocycline. Methods :Minocycline hydrochloride concentration in plasma was measured by an improved HPLC method,and the pharmacokinetic parameters were calculated. Results :After single dose administration of 200 mg minocycline,the main pharmacokinetic parameters t1/2,Cmax,tmax,AUC0→72h,AUC0→∞were(18.1±4.07) h,(4.744±0.887) mg/L,2.0 h,(75.71 ±10.68) mg·h/L,(79.90±12.81) mg·h/L,respectively. Conclusion :The main pharmacokinetic parameters of minocycline are consistent with those reported previously.

GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.
Citation: GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.
shu

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