Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(3): 179-182,217

LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
Citation: LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
shu

Studies on orally disintegrating tablet of caffeine

  • 1.

    School of pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of pharmacy, Tongji Hospital of Tongji University, Shanghai 200065, China

  • 3.

    Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China

  • Received Date: 2008-09-16
  • Objective :To optimize the formula of caffeine orally disintegrating tablet and to investigate the related indexes. Methods :Taking the contents of L-HPC,MCC(disintegrating agent)as disintegrants and the disintegrating time(td)as evaluation indexes to carry out the orthogonal experiment to optimize the formula.The dissolution curve of the optimized formula was drawn. Results :The optimized formula for caffeine orally disintegrating tablet was as follows:the contents of caffeine,MCC,L-HPC,and mannitol were 100,40,25,and 105 mg,respectively.The prepared orally disintegrating tablets disintegrated completely within 30 s and dissolved basically within 2 min. Conclusion :This preparation method of oralhy disintegranting tablet of caffeine is simple and available.Determination method has high accuracy and recovery.It is a suitable method for the preparation and content determination of caffeine orally disintegranting tablet.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2571) PDF downloads(652) Cited by()

Related
Proportional views

Studies on orally disintegrating tablet of caffeine

  • 1. School of pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of pharmacy, Tongji Hospital of Tongji University, Shanghai 200065, China
  • 3. Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China
  • Received Date: 2008-09-16

Abstract: Objective :To optimize the formula of caffeine orally disintegrating tablet and to investigate the related indexes. Methods :Taking the contents of L-HPC,MCC(disintegrating agent)as disintegrants and the disintegrating time(td)as evaluation indexes to carry out the orthogonal experiment to optimize the formula.The dissolution curve of the optimized formula was drawn. Results :The optimized formula for caffeine orally disintegrating tablet was as follows:the contents of caffeine,MCC,L-HPC,and mannitol were 100,40,25,and 105 mg,respectively.The prepared orally disintegrating tablets disintegrated completely within 30 s and dissolved basically within 2 min. Conclusion :This preparation method of oralhy disintegranting tablet of caffeine is simple and available.Determination method has high accuracy and recovery.It is a suitable method for the preparation and content determination of caffeine orally disintegranting tablet.

LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
Citation: LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return