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Volume 27 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(2): 129-131

Geng Li-wen, Bo Wan-lan, Liang Tao. Effect and mechanism of arsenic trioxide on LRP expression on human gastric carcinoma cells[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 129-131.
Citation: Geng Li-wen, Bo Wan-lan, Liang Tao. Effect and mechanism of arsenic trioxide on LRP expression on human gastric carcinoma cells[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 129-131.
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Effect and mechanism of arsenic trioxide on LRP expression on human gastric carcinoma cells

  • 1.

    Second people's hospital of Yuhuan, Yuhuan 317605, China

  • 2.

    First Affiliated Hospital, Harbin Medical University, Harbin 150001, China

  • Received Date: 2008-10-06
  • Objective :To study the apoptosis and mechanism of arsenicals on human gastric carcinoma cells. Methods : MTT,FCM and RT-PCR tests were used to investigate of apoptosis levels induced by arsenic trioxide and the effect on LRP、C-myc expression. Results :1.0 μmol/L and 2.0 μmol/L arsenic trioxide can decrease LRP、C-myc expression. Conclusions :Low concentrations may improve apoptosis of gastric cancer by decreasing LRP、C-myc expression.As2O3 may be used to treat gastric cancer but the results are no better than cisplatin.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect and mechanism of arsenic trioxide on LRP expression on human gastric carcinoma cells

  • 1. Second people's hospital of Yuhuan, Yuhuan 317605, China
  • 2. First Affiliated Hospital, Harbin Medical University, Harbin 150001, China
  • Received Date: 2008-10-06

Abstract: Objective :To study the apoptosis and mechanism of arsenicals on human gastric carcinoma cells. Methods : MTT,FCM and RT-PCR tests were used to investigate of apoptosis levels induced by arsenic trioxide and the effect on LRP、C-myc expression. Results :1.0 μmol/L and 2.0 μmol/L arsenic trioxide can decrease LRP、C-myc expression. Conclusions :Low concentrations may improve apoptosis of gastric cancer by decreasing LRP、C-myc expression.As2O3 may be used to treat gastric cancer but the results are no better than cisplatin.

Geng Li-wen, Bo Wan-lan, Liang Tao. Effect and mechanism of arsenic trioxide on LRP expression on human gastric carcinoma cells[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 129-131.
Citation: Geng Li-wen, Bo Wan-lan, Liang Tao. Effect and mechanism of arsenic trioxide on LRP expression on human gastric carcinoma cells[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 129-131.
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