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Volume 27 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(2): 126-128

SHEN Yang, LUAN Jie, ZHANG Su, WANG Shen-dong, ZHANG Chuan, WANG Jia-chun. Effect of Sodium danshensu on oxygen consumption in anesthetized dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 440-444,444.
Citation: MAO Jun-Qin, YI Jia, LI Tie-Jun. Studies on the anti-depressant effects of Akebia fruit alcohol extract[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 126-128.
shu

Studies on the anti-depressant effects of Akebia fruit alcohol extract

  • 1.

    Department of Pharmacy, the 85th Hospital of PLA, Shanghai 200053, China

  • 2.

    Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-12-08
  • Objective : To investigate the anti-depressant effects of Akebia fruit alcohol extract and to explore its mechanism. Methods :Tail suspension model and force-swim model of mice were used to observe the effect of Akebia fruit alcohol extract on relieving depression.The mechanism was examined by inhibiting reuptake of monoamine neurotransmitters. Results :Akebia fruit alcohol extract can reduced the immobility time in both of the tail suspension test and the forced swim test of mice.Akebia fruit alcohol extract significantly increased the rate of death of injecting dopamine and enhanced the apomorphine-induced stereotypy,could increase the head-twitch response evoked by 5-HTP,but it had no direct activation on reuptake of noradrenalin. Conclusion :Akebia fruit alcohol extract has antidepressant effects,and its mechanism may be related to the reinforcement of 5-HT nerves system and DA nerves system.
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Studies on the anti-depressant effects of Akebia fruit alcohol extract

  • 1. Department of Pharmacy, the 85th Hospital of PLA, Shanghai 200053, China
  • 2. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-12-08

Abstract: Objective : To investigate the anti-depressant effects of Akebia fruit alcohol extract and to explore its mechanism. Methods :Tail suspension model and force-swim model of mice were used to observe the effect of Akebia fruit alcohol extract on relieving depression.The mechanism was examined by inhibiting reuptake of monoamine neurotransmitters. Results :Akebia fruit alcohol extract can reduced the immobility time in both of the tail suspension test and the forced swim test of mice.Akebia fruit alcohol extract significantly increased the rate of death of injecting dopamine and enhanced the apomorphine-induced stereotypy,could increase the head-twitch response evoked by 5-HTP,but it had no direct activation on reuptake of noradrenalin. Conclusion :Akebia fruit alcohol extract has antidepressant effects,and its mechanism may be related to the reinforcement of 5-HT nerves system and DA nerves system.

SHEN Yang, LUAN Jie, ZHANG Su, WANG Shen-dong, ZHANG Chuan, WANG Jia-chun. Effect of Sodium danshensu on oxygen consumption in anesthetized dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 440-444,444.
Citation: MAO Jun-Qin, YI Jia, LI Tie-Jun. Studies on the anti-depressant effects of Akebia fruit alcohol extract[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 126-128.
shu

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