Study on the synthesis of replaced imidazole

LI Ya-nan; LI Yao-wu; ZHEN Can-hui; LU jia-guo; TANG Hui; ZHANG Jue; ZHOU You-jun

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Volume 26 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2008 > (6): 447-449

LI Ya-nan, LI Yao-wu, ZHEN Can-hui, LU jia-guo, TANG Hui, ZHANG Jue, ZHOU You-jun. Study on the synthesis of replaced imidazole[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 447-449.

Citation:

LI Ya-nan, LI Yao-wu, ZHEN Can-hui, LU jia-guo, TANG Hui, ZHANG Jue, ZHOU You-jun. Study on the synthesis of replaced imidazole[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 447-449.

Study on the synthesis of replaced imidazole

1.
School Pharmacy,Second Military Medical University,Shanghai 200433,China
2.
Department of Pharmacy,Air Force General Hospital,Beijing 100142,China

Received Date: 2008-09-28

Abstract

Objective: To optimize the synthesis of replaced imidazole. Methods: Orthogonal experimental design was used and the influence of temperature,reactant ratio and solvent on the yield were investigated. Results: Reactant ratio was more important than the others.The yield was improved from less than 10%to 42.5%. Conclusion: The optimal preparation procedure is stable and available for industrial production.
- replaced imidazole,
- synthesis,
- orthogonal experimental design
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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