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Volume 26 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (6): 422-426

XU Wen-ya, GUO Wei, GU Xiao-hui, YANG Xin-peng, ZHANG Chen, LV Rong, WEI Hong-chang. Protective effect of Yixin oral liquid preconditoning on acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 422-426.
Citation: XU Wen-ya, GUO Wei, GU Xiao-hui, YANG Xin-peng, ZHANG Chen, LV Rong, WEI Hong-chang. Protective effect of Yixin oral liquid preconditoning on acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 422-426.
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Protective effect of Yixin oral liquid preconditoning on acute myocardial ischemia in rats

  • Department of Pathology, Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

  • Received Date: 2007-12-26
  • Objective: To investigate the protective effect of Yixin oral liquid(YOL)preconditoning on acute myocardial ischemia in rats. Methods: The model of acute myocardial ischemia was established on rats by left coronary artery ligation,then the rats were divided into 7 groups randomly:sham operation group,Model group,Diltiazem hydrochloride group,Fufang Danshen Dripping Pills group(FD) and various concentration of YOL groups(high,medium and low doses).The change of J point of ECG,the left ventricular function (LVSP,LVEDP,±dp/dtmax),the superoxide dismutase(SOD)and malonaldehyde(MDA)contents in serum,and the pathologic structure of ischemic rats were observed. Results: The YOL preconditoning could obviously antagonize J point raise and deterioration of left ventricular function compared with the model group(P<0.05),in which the high and medium dose groups with YOL are better;and there were no significant difference between FD group and the high and medium-dose with YOL group.The high and medium dose group with YOL raised SOD level and decreased MDA level in serum,and also ameliorated myocardial pathologic structure changes in acute ischemia rat. Conclusion: YOL preconditioning contributes to protective effect on acute myocardial ischemia in rats.
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Protective effect of Yixin oral liquid preconditoning on acute myocardial ischemia in rats

  • Department of Pathology, Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
  • Received Date: 2007-12-26

Abstract: Objective: To investigate the protective effect of Yixin oral liquid(YOL)preconditoning on acute myocardial ischemia in rats. Methods: The model of acute myocardial ischemia was established on rats by left coronary artery ligation,then the rats were divided into 7 groups randomly:sham operation group,Model group,Diltiazem hydrochloride group,Fufang Danshen Dripping Pills group(FD) and various concentration of YOL groups(high,medium and low doses).The change of J point of ECG,the left ventricular function (LVSP,LVEDP,±dp/dtmax),the superoxide dismutase(SOD)and malonaldehyde(MDA)contents in serum,and the pathologic structure of ischemic rats were observed. Results: The YOL preconditoning could obviously antagonize J point raise and deterioration of left ventricular function compared with the model group(P<0.05),in which the high and medium dose groups with YOL are better;and there were no significant difference between FD group and the high and medium-dose with YOL group.The high and medium dose group with YOL raised SOD level and decreased MDA level in serum,and also ameliorated myocardial pathologic structure changes in acute ischemia rat. Conclusion: YOL preconditioning contributes to protective effect on acute myocardial ischemia in rats.

XU Wen-ya, GUO Wei, GU Xiao-hui, YANG Xin-peng, ZHANG Chen, LV Rong, WEI Hong-chang. Protective effect of Yixin oral liquid preconditoning on acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 422-426.
Citation: XU Wen-ya, GUO Wei, GU Xiao-hui, YANG Xin-peng, ZHANG Chen, LV Rong, WEI Hong-chang. Protective effect of Yixin oral liquid preconditoning on acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 422-426.
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