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Volume 26 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (5): 354-356

FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
Citation: FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
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Content determination of citrate in sodium citrate injection for catheter locking by HPLC

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China

  • Received Date: 2007-09-27
  • Objective:To establish a content determination method of citrate in sodium citrate injection for catheter locking. Methods:HPLC was used to determine citrate on Diamonsil C18 column（250 mm×4.6 mm,5μm）,using MeOH:0.05 mol/L KH2PO4（adjusted to pH 2.5～2.8 by H3PO4）（5:95,v:v）as a mobile phase with a flow rate at 1.0 mL/min and UV wavelengh of 210 nm.Results:The calibration curve of citrate was line in the range of 0.5～6 mg/mL（r=0.999 9,n=5）.The average recovery was 98.79% （RSD=1.08%）.The relative contents of citrate in three batch of citrate in sodium citrate injection for catheter locking were 100.51%,98.22% and 97.78%,respectively.Conclusion:This method was simple,rapid,accurate and suitable for the quality control of citrate.
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Content determination of citrate in sodium citrate injection for catheter locking by HPLC

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China
  • Received Date: 2007-09-27

Abstract: Objective:To establish a content determination method of citrate in sodium citrate injection for catheter locking. Methods:HPLC was used to determine citrate on Diamonsil C18 column（250 mm×4.6 mm,5μm）,using MeOH:0.05 mol/L KH2PO4（adjusted to pH 2.5～2.8 by H3PO4）（5:95,v:v）as a mobile phase with a flow rate at 1.0 mL/min and UV wavelengh of 210 nm.Results:The calibration curve of citrate was line in the range of 0.5～6 mg/mL（r=0.999 9,n=5）.The average recovery was 98.79% （RSD=1.08%）.The relative contents of citrate in three batch of citrate in sodium citrate injection for catheter locking were 100.51%,98.22% and 97.78%,respectively.Conclusion:This method was simple,rapid,accurate and suitable for the quality control of citrate.

FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
Citation: FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
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