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Volume 26 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (5): 350-352

LI Rong, LI Ming, GE Wen-jun. Comparison of dissolution of loratadine tablets or capsules in vitro from five manufacturers[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 350-352.
Citation: LI Rong, LI Ming, GE Wen-jun. Comparison of dissolution of loratadine tablets or capsules in vitro from five manufacturers[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 350-352.
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Comparison of dissolution of loratadine tablets or capsules in vitro from five manufacturers

  • Subei People's Hospital of Jiangsu Province,Yangzhou 225002,China

  • Received Date: 2007-11-01
  • Objective:To compare the dissolution of loratadine tablets or capsules in vitro from five different pharmaceutical facto- ries and give suggestions for clinical use.Methods:The dissolution tests were carried out with rotating basket and the content of lorata- dine was determined by UV spectrophotometry.The accumulation dissolution percent was calculated and Weibull formula was used to fit the deta.The dissolution parameters was statistically analyzed by variance analysis and Q test.Results:The dissolution of loratadine tablets or capsules in vitro from five factories were all in conformity with Chinese Pharmacopoeia（2005 edition）.But significant differ- ences of dissolution parameters m,Kr,T30,T50,Td and T80 were found among the loratadine tablets or capsules from five factories（P<0.05）.Conclusion:There is a significant difference in dissolution parameters of the loratadine tablets or capsules from five factories, indicating that attention should be paid to their difference in clinical use.
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Comparison of dissolution of loratadine tablets or capsules in vitro from five manufacturers

  • Subei People's Hospital of Jiangsu Province,Yangzhou 225002,China
  • Received Date: 2007-11-01

Abstract: Objective:To compare the dissolution of loratadine tablets or capsules in vitro from five different pharmaceutical facto- ries and give suggestions for clinical use.Methods:The dissolution tests were carried out with rotating basket and the content of lorata- dine was determined by UV spectrophotometry.The accumulation dissolution percent was calculated and Weibull formula was used to fit the deta.The dissolution parameters was statistically analyzed by variance analysis and Q test.Results:The dissolution of loratadine tablets or capsules in vitro from five factories were all in conformity with Chinese Pharmacopoeia（2005 edition）.But significant differ- ences of dissolution parameters m,Kr,T30,T50,Td and T80 were found among the loratadine tablets or capsules from five factories（P<0.05）.Conclusion:There is a significant difference in dissolution parameters of the loratadine tablets or capsules from five factories, indicating that attention should be paid to their difference in clinical use.

LI Rong, LI Ming, GE Wen-jun. Comparison of dissolution of loratadine tablets or capsules in vitro from five manufacturers[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 350-352.
Citation: LI Rong, LI Ming, GE Wen-jun. Comparison of dissolution of loratadine tablets or capsules in vitro from five manufacturers[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 350-352.
shu

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