Study on preparation and skin permeation of solid lipid nanoparticles containing felodipine

Key words: 
• felodipine /
• solid lipid nanoparticles /
• transdermal absorption

Abstract: Objective:To develop a new transdermal drug delivery system(solid lipid nanoparticles)for felodipine to improve its effect.Methods:Solid lipid nanoparticles were prepared by solvent-dispersion techique and were treated further by sonication.The release rate and permeation rate of felodipine were studied through excised rat skin in vitro.Results:Solid lipid nanoparticles containing felodipine were spherelike.The particle size was 50～150 nm;the drug entrapped efficiency was higher than 85%;the drug loading was not less than 7%.The release of felodipine from solid lipid nanoparticles followed the first grade model kinetics and the permeation rate of felodipine was remarkably higher in vitro than placebo.Conclusion:The formulation of solid lipid nanoparticles containing felodipine is reasonable.Solid lipid nanoparticles might be a suitable system for transdermal drug delivery.