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Volume 26 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (4): 291-293

GUAN Hao-yue, ZHANGChun, GU Wei-feng. Determination of nefopam hydrochloride(NFH) in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 291-293.
Citation: GUAN Hao-yue, ZHANGChun, GU Wei-feng. Determination of nefopam hydrochloride(NFH) in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 291-293.
shu

Determination of nefopam hydrochloride(NFH) in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China

  • Received Date: 2007-06-11
  • Objective: To establish a method for the content determination of NFH in NFH-13-cyclodextrin inclusion compound. Methods: The drug concentration in NFH-β-eyelodextrin inclusion compound was detected at the wavelength of 267 nm by UV spectro- photometry.The free NFH was eluated by eetoaeetate.The enveloped NFH and its entrapment efficiency were detected by UV spectro- photometry. Results: The linear range of NFH was O.01～0.4 mg/mL (r=0.999 5,n=9);the within day RSD and between-day were 0.17% and 1.82% (u=5),respectively.The average recovery was 100.39% (n=9).The entrapment efficiencies of 3 batches of samples were 73.28%,70.37%,74.97%. Conclusion:: The method is simple and reliable,which can be used for the content determi- nation of NFH in NFH-β-cyclodextrin inclusion compound.
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Determination of nefopam hydrochloride(NFH) in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China
  • Received Date: 2007-06-11

Abstract: Objective: To establish a method for the content determination of NFH in NFH-13-cyclodextrin inclusion compound. Methods: The drug concentration in NFH-β-eyelodextrin inclusion compound was detected at the wavelength of 267 nm by UV spectro- photometry.The free NFH was eluated by eetoaeetate.The enveloped NFH and its entrapment efficiency were detected by UV spectro- photometry. Results: The linear range of NFH was O.01～0.4 mg/mL (r=0.999 5,n=9);the within day RSD and between-day were 0.17% and 1.82% (u=5),respectively.The average recovery was 100.39% (n=9).The entrapment efficiencies of 3 batches of samples were 73.28%,70.37%,74.97%. Conclusion:: The method is simple and reliable,which can be used for the content determi- nation of NFH in NFH-β-cyclodextrin inclusion compound.

GUAN Hao-yue, ZHANGChun, GU Wei-feng. Determination of nefopam hydrochloride(NFH) in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 291-293.
Citation: GUAN Hao-yue, ZHANGChun, GU Wei-feng. Determination of nefopam hydrochloride(NFH) in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 291-293.
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