Comparison of antidepressant effects between Yukexin capsule and its components on mouse models of depression

Key words: 
• Yukexin capsule /
• antidepressant effect /
• mouse tail suspension test /
• mouse forced swimming test

Abstract: Objective: To compare the antidepressant effects of Yukexin capsule and its components on depressive mouse models. Methods: The mice were randomly divided into 5 groups:a control group,a fluoxetine group、a hypericum perforatum group,and the other components.By Using mouse tail suspension test(TST),mouse forced swim test (FST) and reserpine reversal,the antidepres- sant effects of Yukexin capsule and its components were observed.Result:Yukexin capsule shortened the immobility time of tailing suspension and furced swimming of the mice,and could also reverse the ptosis induced by reserpine,hut the symptoms were not notely affected by its components. Conclusion:: hese results suggest that Yukexin capsule,as a complex of active components,can obviously improve all the symptoms of the depressive models through the synergistie actions of the active components in it.