The comparative studies on the analgesic and anti-inflammatory activities of different parts from Crocus sativus

Key words: 
• Crocus sativus L /
• medicinal parts /
• analgesic activity /
• anti-inflammatory activity

Abstract: Objective: To expand new pharmacological resource,traditional plant Crocus sativus L.and to find new pharmacologi- cal active parts to take place of traditional pharmacological part,stigma. Methods: The methods of an abdominal constriction induced by acetic-acid and xylene-induced mice ear edema were used to investigate the analgesic and anti-inflammatory effects of different ex- tracts from Crocus sativus,respectively.Indomethacin and dexamethasone were used as positive control of analgesic and anti-inflamma- tory tests,respectively.The extracts included EtOH extract of corm (CE),apical bud (AE),lateral bud (LE),stigma (SE),the a- queous extract of corm (CA),apical bud (AA),lateral bud (LA),and stigma (SA).Result:In the analgesic tests,compared with negative control,the extracts from apical bud and stigma of ethanol and aqueous ( AE,SE,AA,SA) and lateral bud extract of ethanol at the dose of 2.0 g/kg showed significant (P<0.05 or P<0.01) analgesic activities.On the contrary,CE,CA,LE(at the dose of 0.75 g/kg and 1.5 g/kg),and LA showed no analgesic activities.In the anti-inflammatory tests,SE and LE of Crocus sativus showed significant anti-inflammatory effects compared with negative control.At the dose of 0.75 g/kg,the SE showed significant anti-inflam- matory effects.However,CA,AA,LA,SA and CE had no anti-inflammatory activities in the tests of xylene-induced mice ear edema. Conclusion:: The studies of apical bud and lateral bud of Crocus sativus instead of stigma of Crocus sativus on analgesic and anti-inflam- mation use worth further discussing.