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Volume 26 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (3): 185-187

CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
Citation: CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
shu

Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents

  • Department of Pharmacy,411 Hospital of PLA,Shanghai 200081,China

  • Received Date: 2007-07-24
  • Objective: To investigate the antidepressant activity of Centalla asiatic triterpenic acid(CATA),and its main comstituerts asiatic acid(AA) and madecassic acid(MA). Methods: The forced swimming test(FST),tail suspension test(TST),open field activity(OFA) test and reserpine-induced ptosis test were carried out to examine the antidepressant activity in mice.Mice immobility duration in FST and TST,spontaneous activity frequency in OFA,and ptosis in reserpine antagonistic test were observed. Results: CATA,AA and MA could significantly shorten mice immobility time in FST at the dosages of 60 and 120 mg/kg and could markedly shorten mice immobility time in TST at the dosages of 30,60 and 120 mg/kg.They could not reduce mice spontaneous activity in OFA.CATA,AA and MA could reduce ptosis mice in reserpine antagonistic test. Conclusion: CATA,AA and MA exert an antidepressant activity in animal models.
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Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents

  • Department of Pharmacy,411 Hospital of PLA,Shanghai 200081,China
  • Received Date: 2007-07-24

Abstract: Objective: To investigate the antidepressant activity of Centalla asiatic triterpenic acid(CATA),and its main comstituerts asiatic acid(AA) and madecassic acid(MA). Methods: The forced swimming test(FST),tail suspension test(TST),open field activity(OFA) test and reserpine-induced ptosis test were carried out to examine the antidepressant activity in mice.Mice immobility duration in FST and TST,spontaneous activity frequency in OFA,and ptosis in reserpine antagonistic test were observed. Results: CATA,AA and MA could significantly shorten mice immobility time in FST at the dosages of 60 and 120 mg/kg and could markedly shorten mice immobility time in TST at the dosages of 30,60 and 120 mg/kg.They could not reduce mice spontaneous activity in OFA.CATA,AA and MA could reduce ptosis mice in reserpine antagonistic test. Conclusion: CATA,AA and MA exert an antidepressant activity in animal models.

CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
Citation: CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
shu

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