Effects of ribonucleic acid II on murine immune functions

Key words: 
• ribonucleic acid Ⅱ /
• immune function

Abstract: Objective: To study the effects of ribonucleic acid Ⅱ on murine immune functions. Methods: Kunming mice （6-8 weeks old） were administered with ribonucleic acid II at dosages of 0.2,1,5,25 mg/kg respectively.Spleen and thymus were weighted and cell-mediated immune functions,humoral immune functions, delayed type hypersensitivity reaction and macrophage function assays were performed by conventional methods. Results: In comparison with control group （0.24±0.09 mm）, 0.2,1,5,25 mg/kg ribonucleic acid Ⅱ increased the foot pad swelling to 0.34±0.18, 0.47±0.14, 0.53±0.17, 0.52±0.20 mm respectively. Lymphocyte proliferation capacity was also enhanced.IgM-PFC number increased significantly to 3 444±842, 4 652±1 114, 5 656±1 569, and 6 560±1 812 per 5×106 spleen cell respectively at the dose of 0.2,1,5,25 mg/kg,significantly higher than that of control.Also, phagocytosis capacity was significantly enhanced. Conclusion: Ribonucleic Acid Ⅱ could improve the immune functions in mice.