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Volume 26 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (1): 17-19

LI Bin, ZHAO Yang, TIAN Ying, DONG Jun-xing. Fast determination of undeclared prescription drugs in Chinese herbal medicines by LS-MS/MS[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 17-19.
Citation: LI Bin, ZHAO Yang, TIAN Ying, DONG Jun-xing. Fast determination of undeclared prescription drugs in Chinese herbal medicines by LS-MS/MS[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 17-19.
shu

Fast determination of undeclared prescription drugs in Chinese herbal medicines by LS-MS/MS

  • Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850, China

  • Received Date: 2007-03-06
  • Rev Recd Date: 2007-03-06
  • Objective: To build up a fast determination method for undeclared prescription drugs in Chinese herbal medicines by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Methods: Multiple reaction monitoring (MRM) mode was employed for the analysis of ten possible prescription drugs, including glibenclamide, sibutramine, etc, in 36 Chinese herbal medicines which were categorized into antidiabetics, antihypertensives, aphrodisiacs, weight reducers, and others, according to pharmaceutical functions. Results: Four antidiabetics (containing glibenclamide), one aphrodisiac (containing sildenafil) and two weight reducers (containing sibutramine) were detected within 10min even without thorough chromatographic separation. Conclusion: LC-MS/MS with MRM mode guaranteed sufficient specificity for qualitative analysis and sensitivity for quantitative analysis, providing an alternative for the rapid analysis of multiple undeclared prescription drugs in Chinese herbal medicines.
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Fast determination of undeclared prescription drugs in Chinese herbal medicines by LS-MS/MS

  • Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850, China
  • Received Date: 2007-03-06
  • Rev Recd Date: 2007-03-06

Abstract: Objective: To build up a fast determination method for undeclared prescription drugs in Chinese herbal medicines by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Methods: Multiple reaction monitoring (MRM) mode was employed for the analysis of ten possible prescription drugs, including glibenclamide, sibutramine, etc, in 36 Chinese herbal medicines which were categorized into antidiabetics, antihypertensives, aphrodisiacs, weight reducers, and others, according to pharmaceutical functions. Results: Four antidiabetics (containing glibenclamide), one aphrodisiac (containing sildenafil) and two weight reducers (containing sibutramine) were detected within 10min even without thorough chromatographic separation. Conclusion: LC-MS/MS with MRM mode guaranteed sufficient specificity for qualitative analysis and sensitivity for quantitative analysis, providing an alternative for the rapid analysis of multiple undeclared prescription drugs in Chinese herbal medicines.

LI Bin, ZHAO Yang, TIAN Ying, DONG Jun-xing. Fast determination of undeclared prescription drugs in Chinese herbal medicines by LS-MS/MS[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 17-19.
Citation: LI Bin, ZHAO Yang, TIAN Ying, DONG Jun-xing. Fast determination of undeclared prescription drugs in Chinese herbal medicines by LS-MS/MS[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 17-19.
shu

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