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Volume 25 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (5): 303-306

HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306.
Citation: HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306.
shu

Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro

  • 1.

    Department of Pharmacy, Fuzhou General Hospital, Fuzhou 350025, China

  • 2.

    Department of Pharmacy, No.180 Hospital of PLA Quanzhou 362000, china

  • 3.

    Shool of pharmacy, Second Military Medical University Shanghai 200433, china

  • Received Date: 2007-07-24
  • Objective :To synthesize metallic salts of norfloxacin(NFLO) and evaluate their bacteriaostatic activities in vitro. Methods : The compounds were syntherized from the starting material norfloxacin and metallic salts.The bateriostatic activities of these new compounds were tested. Results : Five new compounds(NFLO-Ag,,NFLO-Zn,NFLO-Ce,NFLO-Co,NFLO-Bi) were produced and their primary quality criteria were established. Conclusions : The bateriostatic tests showed that these new compounds exhibit more potent antimicrobial activities than sliver sulfadiazine against Escherichia coli,Staphylococcus aureus and Pseudomonas aeruginosa.
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Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro

  • 1. Department of Pharmacy, Fuzhou General Hospital, Fuzhou 350025, China
  • 2. Department of Pharmacy, No.180 Hospital of PLA Quanzhou 362000, china
  • 3. Shool of pharmacy, Second Military Medical University Shanghai 200433, china
  • Received Date: 2007-07-24

Abstract: Objective :To synthesize metallic salts of norfloxacin(NFLO) and evaluate their bacteriaostatic activities in vitro. Methods : The compounds were syntherized from the starting material norfloxacin and metallic salts.The bateriostatic activities of these new compounds were tested. Results : Five new compounds(NFLO-Ag,,NFLO-Zn,NFLO-Ce,NFLO-Co,NFLO-Bi) were produced and their primary quality criteria were established. Conclusions : The bateriostatic tests showed that these new compounds exhibit more potent antimicrobial activities than sliver sulfadiazine against Escherichia coli,Staphylococcus aureus and Pseudomonas aeruginosa.

HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306.
Citation: HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306.
shu

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