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Volume 25 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (5): 295-296,302

ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
Citation: ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
shu

Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice

  • Shanghai University of Traditional Chinese Medecine, Shanghai 201203, China

  • Received Date: 2007-05-14
  • Objective :To study the angiogenesis effects of Shexiang Baoxin pill on cancer. Methods :The model of liver metastasis of colorectal cancer was established on 40 BALB/C nude mice which were xenotransplanted through intraspleen injection of LoVo cells,a human colon cancer cell line.These mice were divided into four groups randomly as following: the high-dose-group with Shexiang Baoxin Pill,the medium-dose-group with Shexiang Baoxin Pill,the low-dose-group with Shexiang Baoxin Pill and the model group.The rats of each group were given intragastric administration every day.After 35 days of treatment,vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and Ⅷ-R Ag were messured by immunohistochemical staining. Results :The contents of VEGF,bFGF and Ⅷ-R Ag in herb groups were significantly lower than that of the model group(P<0.05). Conclusion : Shexiang Baoxin Pill can obviously inhibit the angiogeneses in cancer tissues.
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Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice

  • Shanghai University of Traditional Chinese Medecine, Shanghai 201203, China
  • Received Date: 2007-05-14

Abstract: Objective :To study the angiogenesis effects of Shexiang Baoxin pill on cancer. Methods :The model of liver metastasis of colorectal cancer was established on 40 BALB/C nude mice which were xenotransplanted through intraspleen injection of LoVo cells,a human colon cancer cell line.These mice were divided into four groups randomly as following: the high-dose-group with Shexiang Baoxin Pill,the medium-dose-group with Shexiang Baoxin Pill,the low-dose-group with Shexiang Baoxin Pill and the model group.The rats of each group were given intragastric administration every day.After 35 days of treatment,vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and Ⅷ-R Ag were messured by immunohistochemical staining. Results :The contents of VEGF,bFGF and Ⅷ-R Ag in herb groups were significantly lower than that of the model group(P<0.05). Conclusion : Shexiang Baoxin Pill can obviously inhibit the angiogeneses in cancer tissues.

ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
Citation: ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
shu

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