Determination of tolperisone hydrochloride tablets by HPLC

Key words: 
• HPLC /
• tolperisone hydrochloride tablet /
• determination of content

Abstract: Objective: To establishe a HPLC method for determination of tolperisone hydrochloride tablets. Methods: A Phenome- nex Luna C~(18) column(250 mm×4.6 mm,5μm)was used,the mobile phases was consisted of acetonitrile-0.1 mol/L sodium acetate (25:75)(adjust pH to 3.5 with acetic acid glacial),the flow rate was 1.2mL/min,the detector wavelength was at 261 nm。 Results: The linear range was 20.2～202.0μg,/mL(r=0.99999),the mean average recovery was 99.9% and RSD was 0.6%。 Conclusion: The method is simple,rapid and accurate.It can be used to quality control the tolperisone hydrochloride tablets.