Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets

Key words: 
• 5-ISMN orally disintegrating tablet /
• orthogonal design /

Abstract: Objective: To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods: The orthogonal design was used and HPLC was used to determine the concentration. Results: Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine. Conclusion: Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption.