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Volume 25 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (2): 78-79,87

YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.
Citation: YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.
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Study on the choice of stimulation to motion sickness in rats

  • Center for Evaluation of Drug Safety,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2006-12-25
  • Objective: To compare the effect of four stimulator to induce motion sickness in rats. Methods: 40 male SD rats were di-vided into four groups randomly.The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation.GroupⅠwere stimulated in a rotator with ahernately variable speed for 1h,which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s2 until the angular velocity reached 120°/s.Then the device was decelerated at an angu-lar acceleration of 48°/s2 until rotation stopped.GroupⅡwere treated identically except that they were rotated for 1.5h.GroupⅢwere stimulated with alternately variable speed for 1h,which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s2 un-til the angular velocity reached 120°/s.Then the device was decelerated at the same rate until rotation stopped.GroupⅣwere rotated at 120°/s clockwise around a horizontal axis. Results: Among the four groups,the difference of kaolin intake before and after rotation of groupⅠ,groupⅡand groupⅢwere significantly more than that of control group(groupⅡP＜0.01,groupⅠand groupⅢP＜0.05).The difference of kaolin intake before and after rotation of groupⅡwas more than others(P＜0.01). Conclusion: The rotational stimulation of groupⅠ,groupⅡand groupⅢcan induce motion sickness in rats,and groupⅡwere the most effective.
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Study on the choice of stimulation to motion sickness in rats

  • Center for Evaluation of Drug Safety,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2006-12-25

Abstract: Objective: To compare the effect of four stimulator to induce motion sickness in rats. Methods: 40 male SD rats were di-vided into four groups randomly.The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation.GroupⅠwere stimulated in a rotator with ahernately variable speed for 1h,which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s2 until the angular velocity reached 120°/s.Then the device was decelerated at an angu-lar acceleration of 48°/s2 until rotation stopped.GroupⅡwere treated identically except that they were rotated for 1.5h.GroupⅢwere stimulated with alternately variable speed for 1h,which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s2 un-til the angular velocity reached 120°/s.Then the device was decelerated at the same rate until rotation stopped.GroupⅣwere rotated at 120°/s clockwise around a horizontal axis. Results: Among the four groups,the difference of kaolin intake before and after rotation of groupⅠ,groupⅡand groupⅢwere significantly more than that of control group(groupⅡP＜0.01,groupⅠand groupⅢP＜0.05).The difference of kaolin intake before and after rotation of groupⅡwas more than others(P＜0.01). Conclusion: The rotational stimulation of groupⅠ,groupⅡand groupⅢcan induce motion sickness in rats,and groupⅡwere the most effective.

YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.
Citation: YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.
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