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WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
Citation:
WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
Studies of the pharmacokinetics of compound ampicillin sodium for injection
Guangzhou Institute for Drug Control,Guangzhou 510400,China
Received Date: 2005-01-11
Abstract
Objective:To observe the characteristics of the pharmacokinetics of compound ampicillin sodium for injection.Meth- otis:The pharmacokinetics of ampieillin and probenecid in six rabbits after injection were measured by HPLC. Results: On calculation of quantity of ampieillin sodium,300 mg/kg compound ampicillin sodium increased the half life of ampicillin from(23±10)to(31±15)min and the value of A UC from(8.5±0.9 )to(6.2±0.8)mg/(h·mL),120 mg/kg compound ampicillin sodium increased the value of AUC from(2.8±0.9)to(5.7±1.0)mg/(h·mL),50 mg/kg compound ampicillin sodium increased the value of AUC from(0.7±0.2)to(1.5±0.3)mg/(h·mL). Conclusion: Compound ampicillin sodium for injection can increase the activity of ampicillin sodium.
Abstract: Objective:To observe the characteristics of the pharmacokinetics of compound ampicillin sodium for injection.Meth- otis:The pharmacokinetics of ampieillin and probenecid in six rabbits after injection were measured by HPLC. Results: On calculation of quantity of ampieillin sodium,300 mg/kg compound ampicillin sodium increased the half life of ampicillin from(23±10)to(31±15)min and the value of A UC from(8.5±0.9 )to(6.2±0.8)mg/(h·mL),120 mg/kg compound ampicillin sodium increased the value of AUC from(2.8±0.9)to(5.7±1.0)mg/(h·mL),50 mg/kg compound ampicillin sodium increased the value of AUC from(0.7±0.2)to(1.5±0.3)mg/(h·mL). Conclusion: Compound ampicillin sodium for injection can increase the activity of ampicillin sodium.
WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
Citation:
WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
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WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
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