Separation of Enantiomer of Amlodipine by CE and HPLC

HU Jian-guo; LE Jian; LIU Chang-hai; CHEN Gui-Liang

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Volume 24 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2006 > (5): 289-291

HU Jian-guo, LE Jian, LIU Chang-hai, CHEN Gui-Liang. Separation of Enantiomer of Amlodipine by CE and HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 289-291.

Citation:

HU Jian-guo, LE Jian, LIU Chang-hai, CHEN Gui-Liang. Separation of Enantiomer of Amlodipine by CE and HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 289-291.

Separation of Enantiomer of Amlodipine by CE and HPLC

Second Chemistry Department of Shanghai drug control institute, Shanghai 200233, China

Received Date: 2006-01-15

Abstract

Objective: Separation of enantiomer of amlodipine by CE and HPLC. Methods: Different separation conditions such as buffer pH, the concentration of the chiral selector, buffer concentrations, temperature and applied voltage, etc.were studied and op-timized.The separation was finally conducted in 100mM orthophosphoric acid-Tris buffer (pH3.0) with 1.0% (w/w) HP-β-CD.The applied voltage was 16kV and the temperature 15℃. Results: Both CE and HPLC could give enantiomer of amlodipine resolution for adrenaline. Conclusion: The method proved to be specific and accurate
- capillary electrophoresis,
- amlodipine,
- chiral
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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