Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 24 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (5): 264-267

QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
Citation: QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
shu

Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages

  • 1.

    Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2005-09-05
  • Objective: To study the effects of four flavonoids （fisetin, quercetin, apigenin, and phloretin） on production and ac-tions of fibrogenic cytokines. Methods: Mouse peritoneal macrophages were primed with calcimycin 10-6mol/L for 8h then elicited by lipopolysaccharides （LPS） 100g/L for 6h to induce fibrogenic cytokines.Proliferative and collagen stimulating activity in the macro-phage culture supernatants was determined by crystal violet staining assay and [3H]-proline incorporation assay using rat hepatic stel-late HSC-T6 cell.Transforming growth factorβ（TGFβ） activity was measured by [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell. Results: Fisetin, quercetin, apigenin, and phloretin （12.5～50μmol/L） concentration-dependently inhibit LPS-induced collagen stimulating activities and TGFβproduction whereas they did not inhibit proliferative activities released by macro-phages. Conclusion: The four flavonoids reducted fibrogenic cytokines production and blockade of their actions on hepatic stellate cells.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2223) PDF downloads(227) Cited by()

Related
Proportional views

Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages

  • 1. Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2005-09-05

Abstract: Objective: To study the effects of four flavonoids （fisetin, quercetin, apigenin, and phloretin） on production and ac-tions of fibrogenic cytokines. Methods: Mouse peritoneal macrophages were primed with calcimycin 10-6mol/L for 8h then elicited by lipopolysaccharides （LPS） 100g/L for 6h to induce fibrogenic cytokines.Proliferative and collagen stimulating activity in the macro-phage culture supernatants was determined by crystal violet staining assay and [3H]-proline incorporation assay using rat hepatic stel-late HSC-T6 cell.Transforming growth factorβ（TGFβ） activity was measured by [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell. Results: Fisetin, quercetin, apigenin, and phloretin （12.5～50μmol/L） concentration-dependently inhibit LPS-induced collagen stimulating activities and TGFβproduction whereas they did not inhibit proliferative activities released by macro-phages. Conclusion: The four flavonoids reducted fibrogenic cytokines production and blockade of their actions on hepatic stellate cells.

QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
Citation: QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return