Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets

Key words: 
• trifluoperazine hydrochloride /
• oral disintegrating tablets /
• dissolution

Abstract: Objective :To optimize the formulation of the oral disintegrating tablets of trifluoperazine hydrochloride and compare its dissolution profiles with the marketing tablets. Methods : Orthogonal design was used to optimize the formulation of the tablets. The basket method was used to evaluate the dissolution profiles of the tablets. The content of trifluoperazine hydrochloride in the samples was analyzed by UV. Results : When the ratio of gelatia/mannitol/aspartame/trifluoperazine hydrochloride was 0. 15/1/0. 05/0. 16, the tablets has good mouth feel. When the content of crospovidone, L-HPC and microcrystalline cellulose were set at 8%, 5% and 30%, respectively, the disintegration time was within 15s. The cumulative dissolution of the tablets was more than 90% within 5 minute, respectively. Conclusion : The oral disintegrating tablets of trifluoperazine hydrochloride had the advantage of easy administratio-nand its dissolution was significantly higher than that of the market tablets.